SPRO
Spero Therapeutics Inc

SPRO.US sperotherapeutics.com + Research + Basket
Healthcare · Biotechnology
CIK 0001701108
Employees 25
Phone 857 242 1600
Fiscal year end December
IPO Nov 02, 2017
Address 675 Massachusetts Avenue, Cambridge, MA, United States, 02139
1.11
-0.06 (-5.13%)
USD · NASDAQ
52-week range
1.04
3.08
Trading at 3% of the 52-week range
Market Cap
68.13M
P/E Ratio
8.36
Forward P/E
0.00
Book Value
0.76
Div. Yield
N/A
% Institutions
18.26%
% Insiders
22.66%
1 Year

-52.4%
3 Year

+7.8%
10 Year

-90.3%
Description
Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which has completed second Phase 3 trial. It has license agreement with Meiji Seika Pharma Co., Ltd. to develop, manufacture, and commercialize tebipenem pivoxil and tebipenem HBr; and Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries. Spero Therapeutics, Inc. was incorporated in 2013 and is headquartered in Cambridge, Massachusetts.
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People

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Directors & Officers

Name	Title	Year Born
Ms. Esther P. Rajavelu	CEO, President, CFO, Chief Business Officer, Treasurer & Director	1979
Mr. Timothy Keutzer	Chief Operating Officer	1968
Mr. John Raymond	Senior Vice President of Finance & Business Operations	NA
Dr. Debra Jeske Zack M.D., Ph.D.	Chief Medical Officer	1957
Insider Trading

Open insider trading
Date	Insider Name	Title	Transaction Type	Shares	Price	Value	SEC
Feb 06, 2026	Esther Rajavelu	N/A	Sale	87.92K	$2.36	$207.48K	SEC
Feb 02, 2026	Esther Rajavelu	N/A	Sale	18.44K	$2.20	$40.57K	SEC
Nov 07, 2025	Esther Rajavelu	N/A	Sale	40.27K	$2.37	$95.44K	SEC
Aug 28, 2025	Ankit Mahadevia	N/A	Sale	6.57K	$1.97	$12.95K	SEC
Shareholders

▼
Institutional Holders

Holder Name	Shares	Date Reported	% Out	Value	% Change
GSK PLC	9.19M	Jun 30, 2026	15.78%	$3.37	0.00%
Pfizer Inc	2.36M	Jun 30, 2026	4.06%	$3.13	0.00%
Vanguard Capital Management, LLC	2.04M	Jun 30, 2026	3.50%	$0.00	13.13%
Renaissance Technologies Corp	947.90K	Jun 30, 2026	1.63%	$0.00	-20.29%
Alphabet Inc	889.98K	Jun 30, 2026	1.53%	$0.00	0.00%
Susquehanna International Group, LLP	759.29K	Jun 30, 2026	1.30%	$0.00	127.94%
BlackRock Inc	594.40K	Jun 30, 2026	1.02%	$0.00	37.21%
Geode Capital Management, LLC	566.33K	Jun 30, 2026	0.97%	$0.00	8.93%
Two Sigma Investments LLC	382.81K	Jun 30, 2026	0.66%	$0.00	-56.78%
Arrowstreet Capital Limited Partnership	332.97K	Jun 30, 2026	0.57%	$0.00	0.00%
Vanguard Fiduciary Trust Co	287.65K	Jun 30, 2026	0.49%	$0.00	8.91%
GSA Capital Partners LLP	285.91K	Jun 30, 2026	0.49%	$0.04	2.73%
Dimensional Fund Advisors, Inc.	274.82K	Jun 30, 2026	0.47%	$0.00	823.21%
The Goldman Sachs Group Inc	256.99K	Jun 30, 2026	0.44%	$0.00	0.00%
State Street Corp	214.75K	Jun 30, 2026	0.37%	$0.00	0.00%
Jane Street Group LLC	158.10K	Jun 30, 2026	0.27%	$0.00	48.66%
UBS Group AG	139.68K	Jun 30, 2026	0.24%	$0.00	4,542.07%
Bridgeway Capital Management, LLC	114.80K	Jun 30, 2026	0.20%	$0.00	0.00%
Northern Trust Corp	108.27K	Jun 30, 2026	0.19%	$0.00	-10.51%
Point72 Asset Management, L.P.	104.38K	Jun 30, 2026	0.18%	$0.00	74.93%
Fund Holdings

Rank	Holder Name	Shares Held	% of Shares	Change	Date Reported
1	Vanguard MStar Total Stk Mkt Idx Invest	1.40M	2.40%	▲ 0.00%	Sep 30, 2026
2	Mackenzie GQE US Small Cap F8	497.13K	0.85%	▲ 0.00%	Jul 31, 2026
3	iShares Micro-Cap ETF	144.24K	0.25%	▼ 0.69%	Sep 30, 2026
4	Fidelity Total Market Index	107.71K	0.19%	▲ 0.00%	Aug 31, 2026
5	Invesco NASDAQ Future Gen 200 ETF	98.35K	0.17%	▲ 0.00%	Sep 30, 2026
6	Fidelity Extended Market Index	71.72K	0.12%	▼ 71.19%	Aug 31, 2026
7	Fidelity Series Total Market Index	69.79K	0.12%	▲ 0.00%	Aug 31, 2026
8	EA Bridgeway Ultra-Small Company Mkt ETF	63.94K	0.11%	▲ 0.00%	Sep 30, 2026
9	Acuitas US Microcap Institutional	56.46K	0.10%	▲ 0.00%	Jun 30, 2026
10	Bridgeway Omni Small-Cap Value N	50.00K	0.09%	▲ 0.00%	Jun 30, 2026
Financial Highlights

▼
Market Cap: $68.13M
EBITDA: $7.16M
P/E Ratio: $8.36
PEG Ratio: $0.00
Book Value: $0.76
Earnings/Share: $0.14
Profit Margin: 15.71%
Operating Margin: 14.07%
ROA (TTM): 7.19%
ROE (TTM): 19.17%
Revenue (TTM): $47.00M
Revenue/Share (TTM): $0.83
Earnings Growth (YOY): 75.30%
Revenue Growth (YOY): -95.60%
Valuation Metrics

Enterprise Value: $17.66M
Trailing P/E: 8.36
Forward P/E: 0.00
Shares Statistics

Shares Outstanding: 58.23M
Shares Float: 47.10M
% Insiders: 22.66%
% Institutions: 18.26%
Shares Short: 840.53K
Shares Short (Prior Month): 794.51K
Short Ratio: 1.00
Short % Float: 1.74%
Stock Price History

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1 Year Price History

3 Years Price History

10 Years Price History

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Financial Charts

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Open balance sheet Open capital intensity Download Financials (Excel)
Revenue, Net Income & Operating Cash Flow (Yearly)

Change % vs Prior Year

Revenue, Net Income & Operating Cash Flow (Quarterly)

Change % vs Prior Quarter

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Income Statement Waterfall

▼
Line Item
Step Type
Value
Revenue
adjust
$59.62M
Gross Profit
subtotal
$59.62M
SG&A
adjust
$-21.18M
R&D
adjust
$-38.47M
Operating Income
subtotal
$-24.00K
Other / Non-Operating Items
adjust
$8.60M
Net Income
subtotal
$8.57M
Earnings Per Share (EPS) History

▼
Financial Ratios

▼
📦 Raw API Data (JSON Explorer)

▼
Comprehensive raw data returned from the EOD Fundamentals API. Expand sections below to drill down.
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}
Spero Therapeutics Inc

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