SPRO

Spero Therapeutics Inc

SPRO.US sperotherapeutics.com
1.14
+0.01 (+0.44%)
USD · NASDAQ
52-week range
1.08
3.08
Trading at 3% of the 52-week range
Market Cap
65.81M
P/E Ratio
8.07
Forward P/E
0.00
Book Value
0.76
Div. Yield
N/A
% Institutions
18.22%
% Insiders
22.61%

1 Year

-42.1%

3 Year

-13.1%

10 Year

-90.2%
Description

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which has completed second Phase 3 trial. It has license agreement with Meiji Seika Pharma Co., Ltd. to develop, manufacture, and commercialize tebipenem pivoxil and tebipenem HBr; and Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries. Spero Therapeutics, Inc. was incorporated in 2013 and is headquartered in Cambridge, Massachusetts.

Company Information

Company Name
Spero Therapeutics Inc
Sector
Healthcare
Industry
Biotechnology
Exchange
NASDAQ
ISIN: US84833T1034
CIK: 0001701108
CUSIP: 84833T103
Currency: USD
Full Time Employees: 25
Phone: 857 242 1600
Fiscal Year End: December
IPO Date: Nov 02, 2017
Description:

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which has completed second Phase 3 trial. It has license agreement with Meiji Seika Pharma Co., Ltd. to develop, manufacture, and commercialize tebipenem pivoxil and tebipenem HBr; and Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries. Spero Therapeutics, Inc. was incorporated in 2013 and is headquartered in Cambridge, Massachusetts.

Address:

675 Massachusetts Avenue, Cambridge, MA, United States, 02139

People

Directors & Officers

Name Title Year Born
Ms. Esther P. Rajavelu CEO, President, CFO, Chief Business Officer, Treasurer & Director 1979
Mr. Timothy Keutzer Chief Operating Officer 1968
Mr. John Raymond Senior Vice President of Finance & Business Operations NA
Dr. Debra Jeske Zack M.D., Ph.D. Chief Medical Officer 1957
Ms. Sheila Finan Senior VP & Controller NA

Insider Trading

Date Insider Name Title Transaction Type Shares Price Value
Feb 06, 2026 Esther Rajavelu N/A Sale 87.92K $2.36 $207.48K
Feb 02, 2026 Esther Rajavelu N/A Sale 18.44K $2.20 $40.57K
Nov 07, 2025 Esther Rajavelu N/A Sale 40.27K $2.37 $95.44K
Aug 28, 2025 Ankit Mahadevia N/A Sale 6.57K $1.97 $12.95K

Shareholders

Institutional Holders

Holder Name Shares Date Reported % Out Value % Change
GSK PLC 9.19M Mar 31, 2026 15.78% $3.59 0.00%
Pfizer Inc 2.36M Mar 31, 2026 4.06% $2.31 0.00%
Vanguard Capital Management, LLC 1.80M Mar 31, 2026 3.09% $0.00 0.00%
Renaissance Technologies Corp 1.19M Mar 31, 2026 2.04% $0.00 -7.06%
Alphabet Inc 889.98K Jun 30, 2026 1.53% $0.00 0.00%
Geode Capital Management, LLC 519.92K Mar 31, 2026 0.89% $0.00 -1.75%
BlackRock Inc 433.20K Mar 31, 2026 0.74% $0.00 -0.10%
Two Sigma Investments LLC 382.81K Jun 30, 2026 0.66% $0.00 -56.78%
Susquehanna International Group, LLP 333.12K Mar 31, 2026 0.57% $0.00 13.42%
GSA Capital Partners LLP 285.91K Jun 30, 2026 0.49% $0.04 2.73%
Dimensional Fund Advisors, Inc. 274.82K Jun 30, 2026 0.47% $0.00 823.21%
Vanguard Fiduciary Trust Co 264.12K Mar 31, 2026 0.45% $0.00 0.00%
State Street Corp 214.75K Mar 31, 2026 0.37% $0.00 2.19%
Squarepoint Ops LLC 194.30K Mar 31, 2026 0.33% $0.00 62.68%
Marshall Wace Asset Management Ltd 157.07K Mar 31, 2026 0.27% $0.00 0.00%
Northern Trust Corp 120.98K Mar 31, 2026 0.21% $0.00 0.00%
Bridgeway Capital Management, LLC 114.80K Mar 31, 2026 0.20% $0.01 0.00%
Jane Street Group LLC 106.35K Mar 31, 2026 0.18% $0.00 -32.84%
Ionic Capital Management LLC 102.70K Jun 30, 2026 0.18% $0.03 -47.59%
Shay Capital LLC 70.35K Mar 31, 2026 0.12% $0.01 16.69%

Fund Holdings

Rank Holder Name Shares Held % of Shares Change Date Reported
1 Vanguard MStar Total Stk Mkt Idx Invest 1.40M 2.40% ▲ 0.00% Jul 31, 2026
2 Vanguard Institutional Extnd Mkt Idx Tr 593.25K 1.02% ▲ 0.00% Jul 31, 2026
3 Acuitas US Microcap Strategy 462.19K 0.79% ▲ 0.00% Jun 30, 2026
4 Fidelity Extended Market Index 248.94K 0.43% ▼ 0.20% Jul 31, 2026
5 iShares Micro-Cap ETF 150.21K 0.26% ▼ 1.95% Aug 31, 2026
6 Extended Equity Market Fund B 126.66K 0.22% ▲ 0.00% Dec 31, 2025
7 Extended Equity Market Fund E 126.66K 0.22% ▲ 0.00% Dec 31, 2025
8 Blackrock Extended Mkt Fund CF 126.66K 0.22% ▲ 0.00% May 31, 2026
9 Fidelity Total Market Index 107.71K 0.19% ▼ 0.08% Jul 31, 2026
10 BlackRock Extended Equity Market Fund K 107.65K 0.18% ▼ 0.18% Jun 30, 2026

Financial Highlights

Market Cap: $65.81M
EBITDA: $7.16M
P/E Ratio: $8.07
PEG Ratio: $0.00
Book Value: $0.76
Earnings/Share: $0.14
Profit Margin: 15.71%
Operating Margin: 14.07%
ROA (TTM): 7.19%
ROE (TTM): 19.17%
Revenue (TTM): $47.00M
Revenue/Share (TTM): $0.83
Earnings Growth (YOY): 75.30%
Revenue Growth (YOY): -95.60%

Valuation Metrics

Enterprise Value: $17.07M
Trailing P/E: 8.07
Forward P/E: 0.00

Shares Statistics

Shares Outstanding: 58.23M
Shares Float: 46.72M
% Insiders: 22.61%
% Institutions: 18.22%
Short % Float: 2.51%

Stock Price History

1 Year Price History

3 Years Price History

10 Years Price History

Financial Charts

Revenue, Net Income & Operating Cash Flow (Yearly)

Revenue, Net Income & Operating Cash Flow (Quarterly)

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Income Statement Waterfall

Open full waterfall
Line Item
Step Type
Value
Revenue
adjust
$59.62M
Gross Profit
subtotal
$59.62M
SG&A
adjust
$-21.18M
R&D
adjust
$-38.47M
Operating Income
subtotal
$-24.00K
Other / Non-Operating Items
adjust
$8.60M
Net Income
subtotal
$8.57M

Earnings Per Share (EPS) History

Financial Ratios

📦 Raw API Data (JSON Explorer)

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