Stock Fundamentals

Company Information

Company Name
Spero Therapeutics Inc
Sector
Healthcare
Industry
Biotechnology
Exchange
NASDAQ
ISIN: US84833T1034
CIK: 0001701108
CUSIP: 84833T103
Currency: USD
Full Time Employees: 25
Phone: 857 242 1600
Fiscal Year End: December
IPO Date: Nov 02, 2017
Description:

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which has completed second Phase 3 trial. It has license agreement with Meiji Seika Pharma Co., Ltd. to develop, manufacture, and commercialize tebipenem pivoxil and tebipenem HBr; and Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries. Spero Therapeutics, Inc. was incorporated in 2013 and is headquartered in Cambridge, Massachusetts.

Address:

675 Massachusetts Avenue, Cambridge, MA, United States, 02139

Directors & Officers

Name Title Year Born
Ms. Esther P. Rajavelu CEO, President, CFO, Chief Business Officer, Treasurer & Director 1979
Mr. Timothy Keutzer Chief Operating Officer 1968
Mr. John Raymond Senior Vice President of Finance & Business Operations NA
Ms. Sheila Finan Senior VP & Controller NA

Insider Trading

Date Insider Name Title Transaction Type Shares Price Value
Feb 06, 2026 Esther Rajavelu N/A Sale 87.92K $2.36 $207.48K
Feb 02, 2026 Esther Rajavelu N/A Sale 18.44K $2.20 $40.57K
Nov 07, 2025 Esther Rajavelu N/A Sale 40.27K $2.37 $95.44K
Aug 28, 2025 Ankit Mahadevia N/A Sale 6.57K $1.97 $12.95K

Institutional Holders

Holder Name Shares Date Reported % Out Value % Change
GSK PLC 9.19M Mar 31, 2026 15.88% $3.59 0.00%
Pfizer Inc 2.36M Mar 31, 2026 4.08% $2.31 0.00%
Vanguard Group Inc 2.08M Dec 31, 2025 3.60% $0.00 4.70%
Renaissance Technologies Corp 1.19M Mar 31, 2026 2.05% $0.00 -7.06%
Alphabet Inc 889.98K Mar 31, 2026 1.54% $0.05 0.00%
Two Sigma Investments LLC 885.63K Mar 31, 2026 1.53% $0.00 137.71%
Anson Funds Management LP 843.91K Mar 31, 2026 1.46% $0.09 35.01%
Geode Capital Management, LLC 519.92K Mar 31, 2026 0.90% $0.00 -1.75%
BlackRock Inc 433.20K Mar 31, 2026 0.75% $0.00 -0.10%
Citadel Advisors Llc 376.46K Mar 31, 2026 0.65% $0.00 -5.38%
Susquehanna International Group, LLP 333.12K Mar 31, 2026 0.58% $0.00 13.42%
GSA Capital Partners LLP 278.30K Mar 31, 2026 0.48% $0.04 55.54%
Two Sigma Advisers, LLC 216.60K Dec 31, 2025 0.37% $0.00 0.00%
State Street Corp 214.75K Mar 31, 2026 0.37% $0.00 2.19%
Ionic Capital Management LLC 195.94K Mar 31, 2026 0.34% $0.03 0.00%
Squarepoint Ops LLC 194.30K Mar 31, 2026 0.34% $0.00 62.68%
Marshall Wace Asset Management Ltd 157.07K Mar 31, 2026 0.27% $0.00 0.00%
Northern Trust Corp 120.98K Mar 31, 2026 0.21% $0.00 0.00%
Bridgeway Capital Management, LLC 114.80K Mar 31, 2026 0.20% $0.01 0.00%
Jane Street Group LLC 106.35K Mar 31, 2026 0.18% $0.00 -32.84%

Shares Statistics

Shares Outstanding: 57.90M
Shares Float: 46.52M
% Insiders: 2,251.70%
% Institutions: 1,610.70%
Short % Float: 3.43%

Fund Holdings

Rank Holder Name Shares Held % of Shares Change Date Reported
1 Vanguard Total Stock Mkt Idx Inv 1.24M 2.14% ▲ 0.00% Apr 30, 2026
2 Vanguard Institutional Extnd Mkt Idx Tr 516.11K 0.89% ▲ 0.00% Apr 30, 2026
3 Fidelity Extended Market Index 206.60K 0.36% ▼ 0.43% Mar 31, 2026
4 Extended Equity Market Fund B 126.66K 0.22% ▲ 0.00% Dec 31, 2025
5 Blackrock Extended Mkt Fund CF 126.66K 0.22% ▲ 0.00% Apr 30, 2026
6 Extended Equity Market Fund E 126.66K 0.22% ▲ 0.00% Dec 31, 2025
7 BlackRock Extended Equity Market Fund K 107.85K 0.19% ▼ 0.73% Mar 31, 2026
8 Fidelity Total Market Index 107.80K 0.19% ▲ 0.00% Mar 31, 2026
9 JPM Mlt-Mgr Alts C acc USD 70.18K 0.12% ▲ 0.00% Mar 31, 2026
10 Fidelity Series Total Market Index 67.36K 0.12% ▲ 10.12% Mar 31, 2026

Valuation Metrics

Enterprise Value: $109.63M
Trailing P/E: 10.65
Forward P/E: 0.00

Financial Highlights

Market Cap: $166.47M
EBITDA: $7.16M
P/E Ratio: $10.65
PEG Ratio: $0.00
Book Value: $1.05
Earnings/Share: $0.27
Profit Margin: 24.90%
Operating Margin: -2,921.71%
ROA (TTM): 12.96%
ROE (TTM): 35.13%
Revenue (TTM): $61.19M
Revenue/Share (TTM): $1.08
Earnings Growth (YOY): 75.30%
Revenue Growth (YOY): -95.60%

Stock Price History

1 Year Price History

2 Years Price History

5 Years Price History

10 Years Price History

Financial Charts

Revenue & Net Income (Yearly)

Revenue & Net Income (Quarterly)

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Earnings Per Share (EPS) History

Financial Ratios

Balance Sheet (Yearly)

Financial Ratios

Date Current Ratio Debt/Equity Debt/Assets Interest Coverage Debt/EBITDA
2025-12-31 7.59x 0.03x 0.14x N/A -81.50x
2024-12-31 2.19x 0.04x 0.58x N/A -0.02x
2023-12-31 3.53x 0.02x 0.41x N/A 0.06x
2022-12-31 5.04x 0.02x 0.39x -16.20x -0.04x
2021-12-31 8.46x 0.02x 0.48x -45.35x -0.02x
2020-12-31 9.70x 0.01x 0.14x N/A -0.01x
2019-12-31 3.58x 0.02x 0.30x N/A -0.02x
2018-12-31 9.37x 0.00x 0.10x -141.27x -0.01x
2017-12-31 10.70x 0.00x 0.09x -137.72x -0.01x
2016-12-31 1.72x 0.00x 0.54x N/A 0.00x
2015-12-31 0.93x 3.73x 1.04x N/A -0.05x

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