Stock Fundamentals

Company Information

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Company Name
Syndax Pharmaceuticals Inc
Sector
Healthcare
Industry
Biotechnology
Exchange
NASDAQ
ISIN: US87164F1057
CIK: 0001395937
CUSIP: 87164F105
Currency: USD
Full Time Employees: 298
Phone: 781 419 1400
Website: https://syndax.com
Fiscal Year End: December
IPO Date: Mar 03, 2016
Description:

Syndax Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, develops therapies for the treatment of cancer. Its lead product candidate includes Revuforj (revumenib), a menin inhibitor for the treatment of relapsed or refractory (R/R) acute leukemia; and Niktimvo (axatilimab-csfr), a colony stimulating factor-1 receptor blocking antibody to treat chronic graft-versus-host disease. The company is also developing revumenib for the treatment of R/R acute myeloid leukemia (AML) with a nucleophosmin 1 mutation (mNPM1) and in combination with standard-of-care agents in mNPM1 AML or KMT2Ar acute leukemia, as well as for metastatic colorectal cancer; axatilimab to treat idiopathic pulmonary fibrosis; and Entinostat, a Class 1 HDAC inhibitor. It has an agreement with Eddingpharm International Company Limited for licensing, development, and commercialization of Entinostat. Syndax Pharmaceuticals, Inc. was incorporated in 2005 and is headquartered in New York, New York.

Address:

730 Third Avenue, New York, NY, United States, 10017

Directors & Officers

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Name Title Year Born
Mr. Michael A. Metzger M.B.A. CEO & Director 1971
Mr. Keith Alan Goldan CPA CFO, Treasurer & Chief Accounting Officer 1971
Mr. Luke J. Albrecht J.D. Senior VP, General Counsel & Secretary 1979
Mr. Steven Closter Chief Commercial Officer 1969
Dr. Peter Ordentlich B.Sc., Ph.D. Co-Founder & Chief Scientific Officer 1969
Dr. Richard A. Heyman Ph.D. Co-Founder 1957
Dr. Ronald M. Evans Ph.D. Co-Founder, Advisor and Chair of Scientific Advisory Board 1950
Dr. Michael Downes Ph.D. Co-Founder NA
Sharon Klahre Vice President of Investor Relations & Communications NA
Mr. Kevin McManus Chief People Officer 1969

Institutional Holders

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Holder Name Shares Date Reported % Out Value % Change
BlackRock Inc 8.63M Sep 30, 2025 9.87% $0.00 -17.52%
Kynam Capital Management, LP 8.05M Dec 31, 2025 9.21% $10.81 -5.51%
Vanguard Group Inc 6.23M Dec 31, 2025 7.13% $0.00 21.25%
The Goldman Sachs Group Inc 5.49M Sep 30, 2025 6.28% $0.01 -5.36%
Point72 Asset Management, L.P. 4.26M Sep 30, 2025 4.87% $0.11 100.01%
State Street Corp 3.85M Sep 30, 2025 4.41% $0.00 11.93%
Bank of America Corp 3.70M Sep 30, 2025 4.23% $0.00 -3.68%
Eversept Partners, LP 3.47M Sep 30, 2025 3.97% $3.68 -14.71%
Franklin Resources Inc 2.39M Sep 30, 2025 2.74% $0.01 1.31%
Kingdon Capital Management LLC 2.35M Dec 31, 2025 2.69% $5.87 -6.00%
Hood River Capital Management LLC 2.32M Dec 31, 2025 2.65% $0.53 0.00%
Geode Capital Management, LLC 2.09M Sep 30, 2025 2.39% $0.00 2.05%
Soleus Capital Management, L.P. 2.01M Sep 30, 2025 2.30% $1.56 84.24%
Elmind Capital LP 1.86M Dec 31, 2025 2.12% $11.50 0.00%
UBS Group AG 1.67M Sep 30, 2025 1.92% $0.00 16.66%
Qube Research & Technologies 1.64M Sep 30, 2025 1.88% $0.03 -1.26%
Ensign Peak Advisors Inc 1.60M Dec 31, 2025 1.83% $0.06 97.58%
Nuveen, LLC 1.48M Sep 30, 2025 1.69% $0.01 454.72%
MPM Oncology Impact Management LP 1.38M Sep 30, 2025 1.57% $3.46 0.00%
StemPoint Capital LP 1.34M Dec 31, 2025 1.53% $4.83 -1.96%

Shares Statistics

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Shares Outstanding: 86.91M
Shares Float: 74.69M
% Insiders: 183.90%
% Institutions: 11,911.60%
Short % Float: 28.71%

🏆 Top 10 Institutional Holders

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Rank Holder Name Shares Held % of Shares Change Date Reported
1 BlackRock Inc 8.63M 9.87% ▼ 17.52% Sep 30, 2025
2 Kynam Capital Management, LP 8.05M 9.21% ▼ 5.51% Dec 31, 2025
3 Vanguard Group Inc 6.23M 7.13% ▲ 21.25% Dec 31, 2025
4 The Goldman Sachs Group Inc 5.49M 6.28% ▼ 5.36% Sep 30, 2025
5 Point72 Asset Management, L.P. 4.26M 4.87% ▲ 100.01% Sep 30, 2025
6 State Street Corp 3.85M 4.41% ▲ 11.93% Sep 30, 2025
7 Bank of America Corp 3.70M 4.23% ▼ 3.68% Sep 30, 2025
8 Eversept Partners, LP 3.47M 3.97% ▼ 14.71% Sep 30, 2025
9 Franklin Resources Inc 2.39M 2.74% ▲ 1.31% Sep 30, 2025
10 Kingdon Capital Management LLC 2.35M 2.69% ▼ 6.00% Dec 31, 2025

Valuation Metrics

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Enterprise Value: $1.44B
Trailing P/E: 0.00
Forward P/E: 0.00

Financial Highlights

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Market Cap: $1.89B
EBITDA: $-273.48M
PEG Ratio: $0.00
Book Value: $0.74
Earnings/Share: $-3.60
Profit Margin: -165.60%
Operating Margin: -91.59%
ROA (TTM): -27.25%
ROE (TTM): -161.83%
Revenue (TTM): $172.35M
Revenue/Share (TTM): $1.99
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): 794.90%

Stock Price History

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1 Year Price History

2 Years Price History

5 Years Price History

10 Years Price History

Download Financials (Excel)

Financial Charts

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Revenue & Net Income (Yearly)

Revenue & Net Income (Quarterly)

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Earnings Per Share (EPS) History

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Financial Ratios (Yearly)

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Financial Ratios (Quarterly)

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Earnings History

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Balance Sheet (Yearly)

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Financial Ratios

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Date Current Ratio Debt/Equity Debt/Assets Interest Coverage Debt/EBITDA
2025-12-31 4.40x 0.00x 0.65x -8.08x 0.00x
2024-12-31 5.82x 1.19x 0.60x -68.91x -1.10x
2023-12-31 10.00x 0.00x 0.10x -1,105.55x -0.01x
2022-12-31 16.85x 0.00x 0.06x -48.38x 0.00x
2021-12-31 21.68x 0.05x 0.09x 13.81x 0.77x
2020-12-31 15.84x 0.08x 0.16x -30.30x -0.29x
2019-12-31 3.39x 0.02x 0.50x -36.63x -0.01x
2018-12-31 5.18x 0.25x 0.37x -39.07x -0.17x
2017-12-31 8.45x 0.11x 0.24x -43.60x -0.19x
2016-12-31 10.47x 0.08x 0.23x -45.78x -0.15x
2015-12-31 18.16x 0.03x 0.26x -13.02x -0.09x
2014-12-31 1.20x -2.43x 1.45x N/A -0.65x
2013-12-31 5.33x 0.00x 0.31x N/A 0.00x
2012-12-31 0.03x -0.73x 20.40x N/A -4.06x
2011-12-31 0.33x -0.56x 4.98x -4.85x -0.97x

Insider Trading

Date Insider Name Title Transaction Type Shares Price Value
Feb 09, 2026 Keith A Goldan N/A Sale 3.41K $21.03 $71.71K
Feb 09, 2026 Michael A Metzger N/A Sale 17.16K $21.03 $360.85K
Feb 06, 2026 Keith A Goldan N/A Sale 2.08K $20.62 $42.93K
Feb 06, 2026 Michael A Metzger N/A Sale 7.41K $20.62 $152.84K
Sep 08, 2025 Michael A Metzger N/A Sale 157.31K $16.41 $2.58M
Aug 18, 2025 Dennis Podlesak N/A Sale 19.20K $15.84 $304.13K
Aug 15, 2025 Dennis Podlesak N/A Sale 19.20K $15.54 $298.37K
Jul 16, 2025 Keith A Goldan N/A Sale 1.30K $9.29 $12.04K
Jul 16, 2025 Michael A Metzger N/A Sale 7.53K $9.29 $69.99K

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