Stock Fundamentals

Company Information

Company Name
Pyxis Oncology Inc
Sector
Healthcare
Industry
Biotechnology
Exchange
NASDAQ
ISIN: US7473241013
CIK: 0001782223
CUSIP: 747324101
Currency: USD
Full Time Employees: 44
Phone: 617 453 3596
Fiscal Year End: December
IPO Date: Oct 08, 2021
Description:

Pyxis Oncology, Inc., a clinical stage company, engages in the development of therapeutics to treat solid tumors. Its lead antibody-drug conjugates (ADC) product candidate is PYX-201, an investigational novel ADC consisting of human immunoglobulin G1 (IgG1), which is in Phase 1 clinical trial to treat patients with relapsed or refractory solid tumors; and lead immuno-oncology (IO) product candidate is PYX-106, an investigational fully human IgG1 Siglec-15-targeting antibody that is in Phase 1 clinical trial to treat patients with advanced solid tumors. The company is also developing PYX-107, a CD40 agonist with demonstrated anti-cancer activity in patients with several cancer indications, which is in Phase 2 clinical trial for the treatment of tumors, such as soft tissue sarcomas, esophageal and gastroesophageal junction, cancers, and pancreatic ductal adenocarcinoma. It has in-license agreement with Pfizer Inc. to develop and commercialize ADC product candidates, including micvotabart pelidotin and PYX-203, and other ADC product candidates directed to the licensed targets; and Biosion USA, Inc. for development, manufacture, and commercialization of PYX-106, an IO product candidate. Pyxis Oncology, Inc. was incorporated in 2018 and is headquartered in Boston, Massachusetts.

Address:

321 Harrison Avenue, Boston, MA, United States, 02118

Directors & Officers

Name Title Year Born
Mr. Thomas Civik Interim CEO & Director 1970
Mr. Jitendra Wadhane C.A., CPA Chief Accounting Officer, Senior VP of Finance, Corporate Controller & Principal Financial Officer 1980
Dr. Balu N. Balasubramanian Ph.D. Interim Chief Technology Officer NA
Dr. Jan Pinkas Ph.D. Chief Scientific Officer NA
Mr. Alex Kane M.B.A. Senior Vice President of Investor Relations & Capital Markets NA
Donna Regalado Head of Human Resources NA
Dr. Charles T. Gombar Ph.D. Senior Vice President of Portfolio & Program Management NA
Mr. Stephen T. Worsley MBA Senior VP & Chief Business Officer 1964
Dr. Michael Bui Head of Global Regulatory Affairs NA
Dr. Supriya Roth Ph.D. Head of Commercial Development NA

Institutional Holders

Holder Name Shares Date Reported % Out Value % Change
Pfizer Inc 7.03M Sep 30, 2025 11.30% $3.57 0.00%
GordonMD Global Investments LP 4.12M Dec 31, 2025 6.62% $3.40 0.00%
LAURION CAPITAL MANAGEMENT LP 3.63M Sep 30, 2025 5.82% $0.14 0.00%
TANG CAPITAL MANAGEMENT LLC 2.50M Sep 30, 2025 4.02% $0.21 0.00%
Vanguard Group Inc 2.34M Dec 31, 2025 3.75% $0.00 7.94%
Perceptive Advisors LLC 1.18M Sep 30, 2025 1.89% $0.08 0.00%
Palo Alto Investors, LLC 1.04M Sep 30, 2025 1.67% $0.43 0.00%
Millennium Management LLC 815.33K Sep 30, 2025 1.31% $0.00 -76.97%
Renaissance Technologies Corp 728.38K Dec 31, 2025 1.17% $0.00 26.38%
BlackRock Inc 683.70K Sep 30, 2025 1.10% $0.00 -26.23%
Bank of America Corp 615.92K Sep 30, 2025 0.99% $0.00 2,690.89%
Geode Capital Management, LLC 544.51K Sep 30, 2025 0.87% $0.00 6.57%
683 Capital Management LLC 525.00K Sep 30, 2025 0.84% $0.06 -3.67%
Longaeva Partners L.P. 503.21K Sep 30, 2025 0.81% $0.16 0.00%
UBS Group AG 373.73K Sep 30, 2025 0.60% $0.00 -5.65%
Citadel Advisors Llc 337.36K Sep 30, 2025 0.54% $0.00 0.00%
Decheng Capital LLC 326.81K Sep 30, 2025 0.52% $0.13 0.00%
Jane Street Group LLC 303.70K Sep 30, 2025 0.49% $0.00 -9.64%
Schulhoff & CO Inc 275.00K Sep 30, 2025 0.44% $0.26 0.00%
State Street Corp 202.06K Sep 30, 2025 0.32% $0.00 8.60%

Shares Statistics

Shares Outstanding: 62.26M
Shares Float: 39.83M
% Insiders: 2,266.20%
% Institutions: 3,789.20%
Short % Float: 4.74%

🏆 Top 10 Institutional Holders

Rank Holder Name Shares Held % of Shares Change Date Reported
1 Pfizer Inc 7.03M 11.30% ▲ 0.00% Sep 30, 2025
2 GordonMD Global Investments LP 4.12M 6.62% ▲ 0.00% Dec 31, 2025
3 LAURION CAPITAL MANAGEMENT LP 3.63M 5.82% ▲ 0.00% Sep 30, 2025
4 TANG CAPITAL MANAGEMENT LLC 2.50M 4.02% ▲ 0.00% Sep 30, 2025
5 Vanguard Group Inc 2.34M 3.75% ▲ 7.94% Dec 31, 2025
6 Perceptive Advisors LLC 1.18M 1.89% ▲ 0.00% Sep 30, 2025
7 Palo Alto Investors, LLC 1.04M 1.67% ▲ 0.00% Sep 30, 2025
8 Millennium Management LLC 815.33K 1.31% ▼ 76.97% Sep 30, 2025
9 Renaissance Technologies Corp 728.38K 1.17% ▲ 26.38% Dec 31, 2025
10 BlackRock Inc 683.70K 1.10% ▼ 26.23% Sep 30, 2025

Valuation Metrics

Enterprise Value: $34.66M
Trailing P/E: 0.00
Forward P/E: 0.00

Financial Highlights

Market Cap: $91.53M
EBITDA: $-80.47M
Book Value: $1.11
Earnings/Share: $-1.58
Profit Margin: 0.00%
Operating Margin: -2,930.25%
ROA (TTM): -34.33%
ROE (TTM): -87.28%
Revenue (TTM): $2.82M
Revenue/Share (TTM): $0.05
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): 0.00%

Stock Price History

1 Year Price History

2 Years Price History

5 Years Price History

10 Years Price History

Download Financials (Excel)

Financial Charts

Revenue & Net Income (Yearly)

Revenue & Net Income (Quarterly)

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Earnings Per Share (EPS) History

Financial Ratios (Yearly)

Financial Ratios (Quarterly)

Earnings History

Balance Sheet (Yearly)

Financial Ratios

Date Current Ratio Debt/Equity Debt/Assets Interest Coverage Debt/EBITDA
2024-12-31 7.49x 0.01x 0.23x N/A -0.02x
2023-12-31 4.84x 0.01x 0.28x N/A -0.02x
2022-12-31 5.90x 0.00x 0.24x -44.67x 0.00x
2021-12-31 14.90x 0.00x 0.07x -11.14x 0.00x
2020-12-31 2.20x -0.04x 2.54x N/A -0.05x
2019-12-31 26.88x 0.00x 1.15x N/A 0.00x

Insider Trading

Date Insider Name Title Transaction Type Shares Price Value
Nov 26, 2024 Pamela Ann Connealy N/A Purchase 88.85K $1.96 $174.15K
Sep 27, 2023 Jitendra Wadhane N/A Purchase 2.50K $1.87 $4.68K
Sep 27, 2023 Pamela Ann Connealy N/A Purchase 6.43K $1.85 $11.89K
Sep 25, 2023 Jitendra Wadhane N/A Purchase 5.00K $1.77 $8.85K
Sep 25, 2023 Pamela Ann Connealy N/A Purchase 12.00K $1.67 $20.04K
Sep 22, 2023 Jitendra Wadhane N/A Purchase 2.50K $1.74 $4.35K
Sep 22, 2023 Pamela Ann Connealy N/A Purchase 5.00K $1.74 $8.70K
Sep 18, 2023 Lara Sullivan N/A Sale 8.54K $2.10 $17.94K
Sep 13, 2023 Lara Sullivan N/A Sale 3.00K $2.27 $6.81K
Sep 11, 2023 Lara Sullivan N/A Sale 20.00K $2.27 $45.40K
Mar 17, 2023 Pfizer Inc N/A Purchase 1.81M $2.76 $5.00M

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