PRTA
Prothena Corporation plc

PRTA.US prothena.com + Research + Basket
Healthcare · Biotechnology
CIK 0001559053
Employees 67
Phone 353 1 236 2500
Fiscal year end December
IPO Dec 21, 2012
Address 77 Sir John Rogerson?s Quay, Dublin, Ireland, D02 VK60
8.47
-0.41 (-4.62%)
USD · NASDAQ
52-week range
7.73
11.80
Trading at 18% of the 52-week range
Market Cap
455.87M
P/E Ratio
0.00
Forward P/E
10.63
Book Value
5.54
Div. Yield
N/A
% Institutions
93.26%
% Insiders
22.85%
1 Year

-19.2%
3 Year

-76.8%
10 Year

-82.3%
Description
Prothena Corporation plc, a late-stage clinical biotechnology company, focuses on discovery and development of novel therapies to treat diseases caused by protein dysregulation. Its product pipeline includes Prasinezumab, an investigational humanized monoclonal antibody which is in Phase 3 clinical trial for the treatment of parkinson's disease and other synucleinopathies. The company also develops Coramitug, an investigational antibody, which is in Phase 3 clinical trial for the treatment of transthyretin amyloidosis; BMS-986446, an anti-tau antibody which is in Phase 2 clinical trial to treat Alzheimer's disease; PRX019, an investigational antibody which is in Phase 1 clinical trial for the treatment of neurodegenerative diseases; and PRX123, a Dual Aß-Tau Vaccine, which is in preclinical trial for treating Alzheimer's disease. In addition, it develops discovery- and late-preclinical-stage programs include TDP-43 CYTOPE for the treatment of amyotrophic lateral sclerosis; PRX012, a next-generation anti-Aß antibody which is in phase 1 clinical trial to treat Alzheimer's disease; and PRX012-TfR, a preclinical program for the treatment of Alzheimer's disease. It has a license, development, and commercialization agreement with F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. to develop and commercialize antibodies that target a-synuclein, including prasinezumab; and master collaboration agreement with Bristol Myers Squibb to develop and commercialize antibodies targeting tau, TDP-43. Prothena Corporation plc was incorporated in 2012 and is based in Dublin, Ireland.
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People

▼
Directors & Officers

Name	Title	Year Born
Dr. Gene G. Kinney Ph.D.	President, CEO & Director	1969
Mr. Tran B. Nguyen M.B.A.	Chief Financial Officer	1974
Mr. Brandon S. Smith	Chief Operating Officer	1975
Dr. Wagner M. Zago Ph.D.	Chief Scientific Officer	1973
Ms. Karin L. Walker CPA	Chief Accounting Officer & Controller	1963
Mr. Mark C. Johnson C.F.A.	Vice President of Investor Relations	NA
Mr. Michael J. Isaacs	General Counsel & Corporate Secretary	NA
Phillip Dolan	Sr. Director & Head of Exploratory Research	NA
Ms. Annie Evans Kingston	Chief Strategy Officer	NA
Insider Trading

Open insider trading
Date	Insider Name	Title	Transaction Type	Shares	Price	Value	SEC
Jan 14, 2025	William P Scully	N/A	Purchase	100.00K	$12.79	$1.28M	SEC
Dec 31, 2024	William P Scully	N/A	Purchase	32.00K	$13.01	$416.32K	SEC
Dec 20, 2024	William P Scully	N/A	Purchase	2.00K	$15.91	$31.82K	SEC
Dec 18, 2024	William P Scully	N/A	Purchase	73.44K	$13.93	$1.02M	SEC
Jan 24, 2024	Karin L. Walker	N/A	Sale	5.00K	$34.00	$170.00K	SEC
Dec 20, 2023	Karin L. Walker	N/A	Sale	5.00K	$37.19	$185.95K	SEC
Nov 30, 2023	Karin L. Walker	N/A	Sale	5.00K	$34.00	$170.00K	SEC
Oct 25, 2023	Karin L. Walker	N/A	Sale	5.00K	$41.04	$205.20K	SEC
Oct 11, 2023	Brandon S. Smith	N/A	Sale	4.00K	$46.75	$187.00K	SEC
Oct 04, 2023	Carol D. Karp	N/A	Sale	5.00K	$46.62	$233.10K	SEC
Sep 27, 2023	Michael J. Malecek	N/A	Sale	5.00K	$47.38	$236.90K	SEC
Sep 19, 2023	Karin L. Walker	N/A	Sale	5.00K	$52.36	$261.80K	SEC
Sep 13, 2023	Brandon S. Smith	N/A	Sale	4.00K	$55.49	$221.96K	SEC
Sep 13, 2023	Hideki Garren	N/A	Sale	2.00K	$55.48	$110.96K	SEC
Sep 06, 2023	Carol D. Karp	N/A	Sale	5.00K	$54.76	$273.80K	SEC
Aug 30, 2023	Michael J. Malecek	N/A	Sale	5.00K	$55.01	$275.05K	SEC
Aug 18, 2023	Karin L. Walker	N/A	Sale	5.00K	$57.18	$285.90K	SEC
Aug 16, 2023	Hideki Garren	N/A	Sale	2.00K	$58.74	$117.48K	SEC
Aug 16, 2023	Brandon S. Smith	N/A	Sale	4.00K	$58.71	$234.84K	SEC
Aug 02, 2023	Wagner M. Zago	N/A	Sale	4.00K	$67.05	$268.20K	SEC
Shareholders

▼
Institutional Holders

Holder Name	Shares	Date Reported	% Out	Value	% Change
FMR Inc	7.20M	Jun 30, 2026	14.02%	$0.00	-4.66%
Rubric Capital Management LP	5.00M	Jun 30, 2026	9.74%	$0.45	0.00%
BlackRock Inc	4.87M	Jun 30, 2026	9.48%	$0.00	4.82%
State Street Corp	2.39M	Jun 30, 2026	4.66%	$0.00	23.47%
Acadian Asset Management LLC	2.01M	Jun 30, 2026	3.92%	$0.02	29.92%
Vanguard Portfolio Management, LLC	1.65M	Jun 30, 2026	3.22%	$0.00	14.20%
D. E. Shaw & Co LP	1.61M	Jun 30, 2026	3.14%	$0.01	-8.61%
ADAR1 Capital Management LLC	1.55M	Jun 30, 2026	3.03%	$0.70	-1.70%
Two Sigma Investments LLC	1.26M	Jun 30, 2026	2.46%	$0.01	4.89%
Palo Alto Investors, LLC	1.14M	Jun 30, 2026	2.23%	$1.55	-5.41%
Geode Capital Management, LLC	1.13M	Jun 30, 2026	2.19%	$0.00	2.52%
Federated Hermes Inc	1.08M	Jun 30, 2026	2.11%	$0.02	2.32%
Morgan Stanley - Brokerage Accounts	995.35K	Jun 30, 2026	1.94%	$0.00	-19.11%
The Goldman Sachs Group Inc	979.73K	Jun 30, 2026	1.91%	$0.00	19.64%
Jacobs Levy Equity Management, Inc.	965.99K	Jun 30, 2026	1.88%	$0.03	-0.62%
Dimensional Fund Advisors, Inc.	905.65K	Jun 30, 2026	1.76%	$0.00	15.72%
Qube Research & Technologies	791.17K	Jun 30, 2026	1.54%	$0.01	28.73%
Renaissance Technologies Corp	697.62K	Jun 30, 2026	1.36%	$0.01	14.83%
Man Group PLC	678.12K	Jun 30, 2026	1.32%	$0.01	77.72%
Mariner Wealth Advisors LLC	625.10K	Jun 30, 2026	1.22%	$0.01	11.01%
Fund Holdings

Rank	Holder Name	Shares Held	% of Shares	Change	Date Reported
1	Fidelity Growth Company Fund	2.19M	4.26%	▼ 1.94%	Aug 31, 2026
2	iShares Russell 2000 ETF	1.12M	2.18%	▼ 1.14%	Sep 30, 2026
3	State Street® SPDR® S&P® Biotech ETF	910.08K	1.77%	▼ 1.88%	Sep 30, 2026
4	Vanguard Explorer Inv	757.20K	1.48%	▲ 22.68%	Jun 30, 2026
5	Fidelity Series Growth Company	723.71K	1.41%	▼ 1.94%	Aug 31, 2026
6	Fidelity Small Cap Index	485.99K	0.95%	▲ 0.96%	Jul 31, 2026
7	Fidelity Select Biotechnology	472.62K	0.92%	▼ 1.93%	Aug 31, 2026
8	Fidelity Growth Company K6	406.94K	0.79%	▼ 1.95%	Aug 31, 2026
9	Federated Hermes MDT Small Cap Core IS	394.35K	0.77%	▲ 0.00%	Jun 30, 2026
10	iShares Biotechnology ETF	349.94K	0.68%	▼ 0.75%	Sep 30, 2026
Financial Highlights

▼
Market Cap: $455.87M
EBITDA: $-59.04M
PEG Ratio: $0.80
Book Value: $5.54
Earnings/Share: $-0.82
Profit Margin: -80.68%
Operating Margin: -1,850.20%
ROA (TTM): -10.67%
ROE (TTM): -14.40%
Revenue (TTM): $54.53M
Revenue/Share (TTM): $1.02
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): -77.10%
Valuation Metrics

Enterprise Value: $186.48M
Trailing P/E: 0.00
Forward P/E: 10.63
Shares Statistics

Shares Outstanding: 51.34M
Shares Float: 33.97M
% Insiders: 22.85%
% Institutions: 93.26%
Shares Short: 7.94M
Shares Short (Prior Month): 8.01M
Short Ratio: 13.61
Short % Float: 18.63%
Stock Price History

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1 Year Price History

3 Years Price History

10 Years Price History

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Financial Charts

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Open balance sheet Open capital intensity Download Financials (Excel)
Revenue, Net Income & Operating Cash Flow (Yearly)

Change % vs Prior Year

Revenue, Net Income & Operating Cash Flow (Quarterly)

Change % vs Prior Quarter

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Income Statement Waterfall

▼
Line Item
Step Type
Value
Revenue
adjust
$9.68M
Cost of Goods Sold
adjust
$-3.70M
Gross Profit
subtotal
$5.98M
SG&A
adjust
$-59.39M
R&D
adjust
$-134.85M
Operating Income
subtotal
$-184.56M
Other / Non-Operating Items
adjust
$-59.53M
Net Income
subtotal
$-244.09M
Earnings Per Share (EPS) History

▼
Financial Ratios

▼
📦 Raw API Data (JSON Explorer)

▼
Comprehensive raw data returned from the EOD Fundamentals API. Expand sections below to drill down.
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                "revenueEstimateHigh": "4400000.00",
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                "growth": "-1.4570",
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                "earningsEstimateNumberOfAnalysts": "8.0000",
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                "revenueEstimateAvg": "790000.00",
                "revenueEstimateLow": "0.00",
                "revenueEstimateHigh": "4400000.00",
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                "earningsEstimateNumberOfAnalysts": "10.0000",
                "earningsEstimateGrowth": "0.1310",
                "revenueEstimateAvg": "32700000.00",
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                "revenueEstimateAvg": "27480000.00",
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}
Prothena Corporation plc

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