Stock Fundamentals

Company Information

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Company Name
Denali Therapeutics Inc
Sector
Healthcare
Industry
Biotechnology
Exchange
NASDAQ
ISIN: US24823R1059
CIK: 0001714899
CUSIP: 24823R105
Currency: USD
Full Time Employees: 517
Phone: 650 866 8547
Website: https://www.denalitherapeutics.com
Fiscal Year End: December
IPO Date: Dec 08, 2017
Description:

Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutics to treat neurodegenerative and lysosomal storage diseases. The company develops Eclitasertib (SAR443122/DNL758) RIPK1 inhibitor program for peripheral inflammatory diseases; DNL343 eIF2B activator program for amyotrophic lateral sclerosis; BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; TAK-594/DNL593 program for frontotemporal dementia-granulin; DNL126 program for MPS IIIA (Sanfilippo Syndrome A); and DNL310 Tividenofusp alfa, an enzyme replacement therapy program for MPS II (Hunter Syndrome). Its Enzyme TransportVehicle (TV) programs include DNL952 for the treatment of Pompe disease; DNL111 for Parkinson's and Gaucher diseases; and DNL622 for Hurler syndrome (MPS I). The company's OTV programs also comprise DNL628 targeting tau for Alzheimer's disease; and DNL422 targeting alpha synuclein for Parkinson's disease, as well as antibody TV program includes DNL921 targeting Abeta for treating Alzheimer's disease. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.

Address:

161 Oyster Point Boulevard, South San Francisco, CA, United States, 94080

Directors & Officers

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Name Title Year Born
Dr. Ryan J. Watts Ph.D. Co-Founder, President, CEO & Director 1976
Dr. Alexander O. Schuth M.D., Ph.D. Co-Founder, CFO, COO & Secretary 1973
Dr. Dana Andersen Chief Technical and Manufacturing Officer NA
Mr. Joe Lewcock Ph.D. Chief Scientific Officer NA
Mr. Chris Walsh J.D. General Counsel NA
Ms. Cindy Dunkle Chief People Officer NA
Ms. Katie Peng Chief Commercial Officer 1972
Mr. Peter Chin M.D. Acting Chief Medical Officer & Head of Development NA

Institutional Holders

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Holder Name Shares Date Reported % Out Value % Change
Vanguard Group Inc 13.06M Dec 31, 2025 8.36% $0.00 8.88%
Baillie Gifford & Co Limited. 12.31M Dec 31, 2025 7.88% $0.17 6.21%
BlackRock Inc 12.29M Sep 30, 2025 7.87% $0.00 1.96%
Temasek Holdings Ltd. 7.01M Dec 31, 2025 4.49% $0.37 30.94%
FMR Inc 6.10M Dec 31, 2025 3.90% $0.01 -3.83%
T. Rowe Price Investment Management,Inc. 5.64M Sep 30, 2025 3.61% $0.05 73.66%
UBS Asset Mgmt Americas Inc 5.47M Sep 30, 2025 3.50% $0.02 -12.73%
State Street Corp 5.46M Sep 30, 2025 3.50% $0.00 20.94%
NORGES BANK 5.12M Dec 31, 2025 3.28% $0.01 29.70%
Capital Research Global Investors 4.76M Sep 30, 2025 3.05% $0.01 0.22%
T. Rowe Price Associates, Inc. 4.57M Sep 30, 2025 2.93% $0.01 -30.60%
Baker Bros Advisors LP 3.73M Dec 31, 2025 2.39% $0.36 0.00%
AllianceBernstein L.P. 3.52M Sep 30, 2025 2.25% $0.02 12.22%
Geode Capital Management, LLC 3.47M Sep 30, 2025 2.22% $0.00 9.26%
Holocene Advisors, LP 3.15M Dec 31, 2025 2.02% $0.11 0.54%
Crestline Management LP 2.81M Dec 31, 2025 1.80% $87.02 -17.59%
Point72 Asset Management, L.P. 2.52M Sep 30, 2025 1.61% $0.06 13.80%
Dimensional Fund Advisors, Inc. 2.37M Dec 31, 2025 1.52% $0.01 0.73%
The Goldman Sachs Group Inc 2.16M Sep 30, 2025 1.39% $0.00 16.00%
Aberdeen Group PLC 2.03M Dec 31, 2025 1.30% $0.05 82.56%

Shares Statistics

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Shares Outstanding: 156.16M
Shares Float: 141.95M
% Insiders: 930.10%
% Institutions: 10,110.60%
Short % Float: 9.67%

🏆 Top 10 Institutional Holders

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Rank Holder Name Shares Held % of Shares Change Date Reported
1 Vanguard Group Inc 13.06M 8.36% ▲ 8.88% Dec 31, 2025
2 Baillie Gifford & Co Limited. 12.31M 7.88% ▲ 6.21% Dec 31, 2025
3 BlackRock Inc 12.29M 7.87% ▲ 1.96% Sep 30, 2025
4 Temasek Holdings Ltd. 7.01M 4.49% ▲ 30.94% Dec 31, 2025
5 FMR Inc 6.10M 3.90% ▼ 3.83% Dec 31, 2025
6 T. Rowe Price Investment Management,Inc. 5.64M 3.61% ▲ 73.66% Sep 30, 2025
7 UBS Asset Mgmt Americas Inc 5.47M 3.50% ▼ 12.73% Sep 30, 2025
8 State Street Corp 5.46M 3.50% ▲ 20.94% Sep 30, 2025
9 NORGES BANK 5.12M 3.28% ▲ 29.70% Dec 31, 2025
10 Capital Research Global Investors 4.76M 3.05% ▲ 0.22% Sep 30, 2025

Valuation Metrics

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Enterprise Value: $2.50B
Trailing P/E: 0.00
Forward P/E: 0.00

Financial Highlights

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Market Cap: $3.31B
EBITDA: $-540.53M
Book Value: $6.49
Earnings/Share: $-2.92
Profit Margin: 0.00%
Operating Margin: 0.00%
ROA (TTM): -27.56%
ROE (TTM): -45.69%
Revenue (TTM): $0.00
Revenue/Share (TTM): $0.00
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): -100.00%

Stock Price History

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1 Year Price History

2 Years Price History

5 Years Price History

10 Years Price History

Download Financials (Excel)

Financial Charts

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Revenue & Net Income (Yearly)

Revenue & Net Income (Quarterly)

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Earnings Per Share (EPS) History

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Financial Ratios (Yearly)

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Financial Ratios (Quarterly)

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Earnings History

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Balance Sheet (Yearly)

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Financial Ratios

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Date Current Ratio Debt/Equity Debt/Assets Interest Coverage Debt/EBITDA
2025-12-31 9.16x 0.00x 0.11x N/A 0.00x
2024-12-31 8.46x 0.01x 0.11x N/A -0.02x
2023-12-31 13.65x 0.01x 0.11x N/A -0.04x
2022-12-31 3.77x 0.01x 0.29x -23.06x -0.02x
2021-12-31 2.37x 0.01x 0.31x -22.43x -0.02x
2020-12-31 20.86x 0.00x 0.28x 3.53x 0.07x
2019-12-31 9.48x 0.01x 0.29x -14.01x -0.02x
2018-12-31 14.67x 0.03x 0.17x -23.72x -0.49x
2017-12-31 28.92x 0.00x 0.04x -46.11x 0.00x
2016-12-31 19.98x 0.00x 0.06x N/A 0.00x
2015-12-31 9.60x 0.00x 1.43x -153.02x 0.00x

Insider Trading

Date Insider Name Title Transaction Type Shares Price Value
Jan 06, 2026 Alexander O Schuth N/A Sale 17.22K $16.50 $284.10K
Jan 06, 2026 Ryan J Watts N/A Sale 35.20K $16.50 $580.77K
Aug 13, 2025 Carole Ho N/A Sale 806.00 $14.64 $11.80K
Aug 12, 2025 Alexander O Schuth N/A Sale 2.94K $13.58 $39.88K
Aug 12, 2025 Carole Ho N/A Sale 2.94K $13.58 $39.88K
Jul 09, 2025 Ryan J Watts N/A Sale 495.28K $15.00 $7.43M

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