AXSM
Axsome Therapeutics Inc

AXSM.US axsome.com
Healthcare · Biotechnology
220.75
+9.64 (+4.56%)
USD · NASDAQ
52-week range
112.90
260.19
Trading at 73% of the 52-week range
Market Cap
11.56B
P/E Ratio
0.00
Forward P/E
35.09
Book Value
1.59
Div. Yield
N/A
% Institutions
74.62%
% Insiders
15.08%
1 Year

+79.5%
3 Year

+168.5%
10 Year

+2,907.5%
Description
Axsome Therapeutics, Inc., a biopharmaceutical company, develops and delivers novel therapies for the management of central nervous system (CNS) disorders in the United States. The company's commercial product portfolio includes Auvelity (dextromethorphan-bupropion), a N-methyl-D-aspartate receptor antagonist, sigma-1 receptor agonist, aminoketone, and CYP2D6 inhibitor indicated for the treatment of major depressive disorder in adults; Sunosi (solriamfetol), a dopamine and norepinephrine reuptake inhibitor, trace amine-associated receptor 1 agonist, and 5-HT1A agonist indicated for the treatment of excessive daytime sleepiness in patients with narcolepsy or obstructive sleep apnea; and Symbravo (MoSEIC meloxicam rizatriptan), or AXS-07, a rapidly absorbed, multi-mechanistic, selective COX-2 inhibitor, and 5-HT1B/1D agonist indicated for the acute treatment of migraine with or without aura. It also develops AXS-05 (dextromethorphan-bupropion), an investigational N-methyl-D-aspartate receptor antagonist, which has completed Phase III clinical trial to treat Alzheimer's disease agitation, as well as that has completed phase II clinical trial for the treatment of smoking cessation; AXS-12 (reboxetine), a highly selective and potent norepinephrine reuptake inhibitor and cortical dopamine modulator, which has completed Phase II trial to treat narcolepsy; AXS-14 (esreboxetine), a selective and potent norepinephrine reuptake inhibitor that has completed Phase III trial for the treatment of fibromyalgia and other conditions; and Solriamfetol, a dopamine and norepinephrine reuptake inhibitor, which is in Phase III trial for treating attention deficit hyperactivity, major depressive, binge eating, and excessive sleepiness associated with shift work disorder. It has a research collaboration agreement with Duke University for evaluating AXS-05 in a Phase 2 clinical trial in smoking cessation treatment. The company was incorporated in 2012 and is based in New York, New York.
People

▼
Directors & Officers

Name	Title	Year Born
Dr. Herriot Tabuteau M.D.	Founder, Chairman, CEO & President	1968
Mr. Nick Pizzie CPA, M.B.A.	Chief Financial Officer	1975
Mr. Mark L. Jacobson M.A.	Chief Operating Officer	1983
Mr. Hunter Murdock Esq.	General Counsel & Secretary	1980
Mr. Ari Maizel M.B.A.	Chief Commercial Officer	1979
Darren Opland	Director of Corporate Communications	NA
Insider Trading

Date	Insider Name	Title	Transaction Type	Shares	Price	Value
Apr 22, 2026	Ari Maizel	N/A	Sale	7.50K	$182.42	$1.37M
Feb 26, 2026	Mark Coleman	N/A	Sale	25.00K	$161.11	$4.03M
Feb 26, 2026	Mark L Jacobson	N/A	Sale	35.38K	$161.88	$5.73M
Feb 02, 2026	Herriot Tabuteau	N/A	Sale	32.41K	$185.60	$6.02M
Jan 22, 2026	Nick Pizzie	N/A	Sale	12.00K	$187.92	$2.26M
Jan 21, 2026	Ari Maizel	N/A	Sale	7.50K	$184.44	$1.38M
Jan 07, 2026	Herriot Tabuteau	N/A	Sale	31.26K	$170.38	$5.33M
Jan 06, 2026	Herriot Tabuteau	N/A	Sale	29.45K	$172.33	$5.08M
Jan 05, 2026	Herriot Tabuteau	N/A	Sale	78.70K	$171.28	$13.48M
Dec 31, 2025	Mark E Saad	N/A	Sale	37.58K	$165.18	$6.21M
Dec 04, 2025	Herriot Tabuteau	N/A	Sale	10.56K	$148.18	$1.56M
Dec 03, 2025	Herriot Tabuteau	N/A	Sale	20.16K	$146.94	$2.96M
Dec 02, 2025	Herriot Tabuteau	N/A	Sale	49.25K	$144.59	$7.12M
Nov 05, 2025	Herriot Tabuteau	N/A	Sale	21.78K	$134.49	$2.93M
Nov 04, 2025	Herriot Tabuteau	N/A	Sale	50.46K	$133.79	$6.75M
Nov 03, 2025	Herriot Tabuteau	N/A	Sale	91.71K	$132.34	$12.14M
Oct 08, 2025	Herriot Tabuteau	N/A	Sale	12.77K	$118.84	$1.52M
Oct 07, 2025	Herriot Tabuteau	N/A	Sale	13.39K	$118.77	$1.59M
Oct 06, 2025	Herriot Tabuteau	N/A	Sale	19.22K	$120.17	$2.31M
Sep 22, 2025	Mark L Jacobson	N/A	Sale	10.00K	$115.96	$1.16M
Shareholders

▼
Institutional Holders

Holder Name	Shares	Date Reported	% Out	Value	% Change
BlackRock Inc	3.91M	Mar 31, 2026	7.47%	$0.01	-0.02%
Vanguard Portfolio Management, LLC	2.06M	Mar 31, 2026	3.93%	$0.02	0.00%
Vanguard Capital Management, LLC	1.94M	Mar 31, 2026	3.70%	$0.01	0.00%
FMR Inc	1.57M	Mar 31, 2026	2.99%	$0.01	32.61%
T. Rowe Price Associates, Inc.	1.32M	Mar 31, 2026	2.51%	$0.03	-12.77%
Amvescap Plc.	1.30M	Mar 31, 2026	2.48%	$0.02	1.90%
Geode Capital Management, LLC	1.16M	Mar 31, 2026	2.22%	$0.01	15.12%
State Street Corp	986.81K	Mar 31, 2026	1.88%	$0.01	2.99%
Delaware Management Holdings Inc	812.81K	Mar 31, 2026	1.55%	$0.24	-17.85%
Deep Track Capital, LP	700.00K	Jun 30, 2026	1.34%	$2.49	-36.36%
Wellington Management Company LLP	653.92K	Jun 30, 2026	1.25%	$0.03	-42.90%
Alethea Capital Management, LLC	649.11K	Mar 31, 2026	1.24%	$56.28	-2.93%
D. E. Shaw & Co LP	604.75K	Jun 30, 2026	1.15%	$0.07	0.21%
Bank of America Corp	598.09K	Mar 31, 2026	1.14%	$0.01	-3.23%
Millennium Management LLC	556.09K	Jun 30, 2026	1.06%	$0.05	2,578.91%
UBS Group AG	547.20K	Mar 31, 2026	1.04%	$0.01	54.00%
NORGES BANK	514.27K	Jun 30, 2026	0.98%	$0.01	3.80%
First Trust Advisors L.P.	482.06K	Jun 30, 2026	0.92%	$0.07	-16.52%
Morgan Stanley - Brokerage Accounts	476.70K	Mar 31, 2026	0.91%	$0.00	-2.95%
Assenagon Asset Management SA	454.68K	Jun 30, 2026	0.87%	$0.14	-47.49%
Fund Holdings

Rank	Holder Name	Shares Held	% of Shares	Change	Date Reported
1	Vanguard MStar Total Stk Mkt Idx Invest	1.39M	2.66%	▲ 0.32%	Jul 31, 2026
2	Vanguard Small Cap Index	1.00M	1.92%	▲ 0.18%	Jul 31, 2026
3	Vanguard MStar Small Cap Growth Indx Inv	581.83K	1.11%	▲ 0.44%	Jul 31, 2026
4	Vanguard Explorer Inv	506.00K	0.97%	▲ 38.47%	Jun 30, 2026
5	Vanguard Institutional Extnd Mkt Idx Tr	497.61K	0.95%	▲ 0.33%	Jul 31, 2026
6	Invesco Discovery A	491.09K	0.94%	▲ 1.98%	Jul 31, 2026
7	Invesco OFI Small Cap Growth	481.54K	0.92%	▼ 0.20%	Jun 30, 2026
8	First Trust NYSE Arca Biotech ETF	387.24K	0.74%	▲ 0.00%	Aug 31, 2026
9	iShares Biotechnology ETF	322.42K	0.62%	▲ 0.54%	Aug 31, 2026
10	Franklin Innovation Composite	311.30K	0.59%	▲ 3.77%	Jul 31, 2026
Financial Highlights

▼
Market Cap: $11.56B
EBITDA: $-172.92M
PEG Ratio: $0.00
Book Value: $1.59
Earnings/Share: $-3.75
Profit Margin: -24.68%
Operating Margin: -23.42%
ROA (TTM): -16.31%
ROE (TTM): -245.10%
Revenue (TTM): $776.57M
Revenue/Share (TTM): $15.25
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): 45.50%
Valuation Metrics

Enterprise Value: $10.96B
Trailing P/E: 0.00
Forward P/E: 35.09
Shares Statistics

Shares Outstanding: 52.38M
Shares Float: 44.46M
% Insiders: 15.08%
% Institutions: 74.62%
Short % Float: 9.12%
Stock Price History

▼
1 Year Price History

3 Years Price History

10 Years Price History

Financial Charts

▼
Download Financials (Excel)
Revenue, Net Income & Operating Cash Flow (Yearly)

Revenue, Net Income & Operating Cash Flow (Quarterly)

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Income Statement Waterfall

▼
Line Item
Step Type
Value
Revenue
adjust
$638.50M
Cost of Goods Sold
adjust
$-47.48M
Gross Profit
subtotal
$591.02M
SG&A
adjust
$-570.60M
R&D
adjust
$-183.28M
Other Operating Expense
adjust
$-6.38M
Operating Income
subtotal
$-169.24M
Other / Non-Operating Items
adjust
$-13.94M
Net Income
subtotal
$-183.17M
Earnings Per Share (EPS) History

▼
Financial Ratios

▼
📦 Raw API Data (JSON Explorer)

▼
Comprehensive raw data returned from the EOD Fundamentals API. Expand sections below to drill down.
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        "Code": "AXSM",
        "Type": "Common Stock",
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                "epsRevisionsUpLast7days": "0.0000",
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                },
                "2013-12-31": {
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                    "sellingGeneralAdministrative": "304183.00",
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                    "ebit": "-1839438.00",
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                    "interestExpense": "327192.00",
                    "taxProvision": null,
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                    "extraordinaryItems": null,
                    "nonRecurring": null,
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                    "incomeTaxExpense": "-1839438.00",
                    "totalRevenue": null,
                    "totalOperatingExpenses": "1839438.00",
                    "costOfRevenue": null,
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                    "discontinuedOperations": null,
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            }
        }
    }
}
Axsome Therapeutics Inc

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