Stock Fundamentals

Company Information

Company Name
Amylyx Pharmaceuticals Inc
Sector
Healthcare
Industry
Drug Manufacturers - Specialty & Generic
Exchange
NASDAQ
ISIN: US0321085088
CIK: 0001658551
CUSIP: 032108508
Currency: USD
Full Time Employees: 136
Phone: 617 682 0917
Fiscal Year End: December
IPO Date: Jan 07, 2022
Description:

Amylyx Pharmaceuticals, Inc., a clinical-stage pharmaceutical company, engages in the discovery and development of treatment options for neurodegenerative diseases and endocrine conditions in the United States. It provides Avexitide, an investigational, first-in-class glucagon-like peptide-1, or GLP-1 receptor antagonist, which is in phase 3 clinical trial to treat post-bariatric hypoglycemia and congenital hyperinsulinism. The company also develops AMX0035, an oral, fixed-dose combination of sodium phenylbutyrate and taurursodiol which is phase 2 clinical trial for the treatment of wolfram syndrome, as well as in phase 2b/3 clinical trial to treat progressive supranuclear palsy; AMX0114, which is in phase 1 clinical trial for the treatment of amyotrophic lateral sclerosis; and long-acting GLP-1 receptor antagonist to treat post-bariatric hypoglycemia and other rare diseases. Further, it develops AMX0318, a GLP-1 receptor antagonist for the treatment of post-bariatric hypoglycemia and other rare diseaees. Amylyx Pharmaceuticals, Inc. was founded in 2013 and is headquartered in Cambridge, Massachusetts.

Address:

55 Cambridge Parkway, Cambridge, MA, United States, 02142

Directors & Officers

Name Title Year Born
Mr. Joshua B. Cohen Co-Founder, Co-CEO & Director 1992
Mr. Justin B. Klee Co-CEO & Director 1991
Mr. James M. Frates M.B.A. Chief Financial Officer 1967
Dr. Camille L. Bedrosian M.D. Chief Medical Officer 1953
Mr. Tom Holmes Chief Technical Operations Officer NA
Ms. Lindsey Allen Head of Investor Relations & Communications NA
Ms. Gina M. Mazzariello J.D. Chief Legal Officer & General Counsel 1972
Ms. Linda A. Arsenault Chief Human Resources Officer NA
Ms. Tammy Sarnelli Global Head of Regulatory Affairs NA
Dr. Machelle Manuel Ph.D. VP & Head of Global Medical Affairs NA

Insider Trading

Date Insider Name Title Transaction Type Shares Price Value
Jan 16, 2026 Joshua B Cohen N/A Sale 1.97K $13.83 $27.30K
Jan 16, 2026 Justin B Klee N/A Sale 2.00K $13.89 $27.71K
Jan 15, 2026 Joshua B Cohen N/A Sale 136.19K $13.59 $1.85M
Jan 06, 2026 James M Frates N/A Sale 3.33K $11.11 $36.95K
Jan 06, 2026 Joshua B Cohen N/A Sale 7.72K $11.09 $85.56K
Dec 23, 2025 Karen Firestone N/A Purchase 8.10K $12.45 $100.85K
Dec 01, 2025 Camille L Bedrosian N/A Sale 6.58K $14.35 $94.42K
Sep 30, 2025 Camille L Bedrosian N/A Sale 12.04K $14.58 $175.53K
Sep 30, 2025 Gina Mazzariello N/A Sale 8.83K $14.58 $128.71K
Sep 30, 2025 James M Frates N/A Sale 10.56K $14.65 $154.67K
Sep 30, 2025 Joshua B Cohen N/A Sale 29.93K $14.35 $429.54K
Sep 30, 2025 Justin B Klee N/A Sale 29.98K $14.38 $431.04K

Institutional Holders

Holder Name Shares Date Reported % Out Value % Change
FMR Inc 16.63M Mar 31, 2026 14.96% $0.01 0.68%
BlackRock Inc 8.83M Mar 31, 2026 7.94% $0.00 -2.49%
Perceptive Advisors LLC 8.28M Mar 31, 2026 7.45% $2.25 0.00%
TCG Crossover Management, LLC 6.24M Mar 31, 2026 5.62% $2.48 0.00%
Vanguard Group Inc 5.80M Dec 31, 2025 5.22% $0.00 10.07%
COMMODORE CAPITAL LP 5.65M Mar 31, 2026 5.08% $4.54 0.00%
HHG PLC 4.99M Mar 31, 2026 4.48% $0.03 11.65%
Saturn V Capital Management LLC 4.35M Mar 31, 2026 3.91% $10.95 -3.26%
Adage Capital Partners Gp LLC 3.56M Mar 31, 2026 3.20% $0.08 28.22%
First Light Asset Management, LLC 3.19M Mar 31, 2026 2.87% $3.97 -4.91%
Driehaus Capital Management LLC 2.99M Mar 31, 2026 2.69% $0.31 -3.93%
The Goldman Sachs Group Inc 2.63M Mar 31, 2026 2.36% $0.00 0.49%
State Street Corp 2.36M Mar 31, 2026 2.13% $0.00 14.17%
Franklin Resources Inc 2.26M Mar 31, 2026 2.03% $0.01 88.45%
Geode Capital Management, LLC 2.21M Mar 31, 2026 1.99% $0.00 2.10%
Morgan Stanley - Brokerage Accounts 2.18M Mar 31, 2026 1.96% $0.00 -7.81%
Almitas Capital LLC 2.12M Dec 31, 2025 1.91% $5.65 -50.00%
Great Point Partners LLC 1.75M Mar 31, 2026 1.57% $5.59 0.00%
683 Capital Management LLC 1.53M Mar 31, 2026 1.38% $1.11 -7.27%
Eventide Asset Management, LLC 1.51M Mar 31, 2026 1.36% $0.35 0.05%

Shares Statistics

Shares Outstanding: 111.19M
Shares Float: 83.53M
% Insiders: 791.60%
% Institutions: 10,509.20%
Short % Float: 16.89%

Fund Holdings

Rank Holder Name Shares Held % of Shares Change Date Reported
1 Vanguard Total Stock Mkt Idx Inv 3.11M 2.80% ▲ 0.31% Apr 30, 2026
2 Fidelity Advisor Biotechnology I 2.43M 2.19% ▲ 0.00% Mar 31, 2026
3 iShares Russell 2000 ETF 2.16M 1.94% ▲ 0.85% Apr 30, 2026
4 Fidelity Small Cap Growth 2.12M 1.90% ▲ 0.00% Feb 28, 2026
5 Eventide Healthcare & Life Sciences I 1.51M 1.36% ▲ 0.00% Dec 31, 2025
6 Fidelity Select Health Care 1.42M 1.28% ▲ 0.00% Mar 31, 2026
7 Xtrackers S&P 500 Swap ETF 1C 1.24M 1.12% ▼ 0.73% Dec 31, 2025
8 Fidelity Select Biotechnology 1.22M 1.10% ▲ 0.00% Mar 31, 2026
9 Strategic Advisers Fidelity US TtlStk 1.14M 1.02% ▲ 0.00% Mar 31, 2026
10 Franklin Biotechnology Discv A(acc)USD 1.11M 1.00% ▲ 7.98% Apr 30, 2026

Valuation Metrics

Enterprise Value: $1.29B
Trailing P/E: 0.00
Forward P/E: 2.77

Financial Highlights

Market Cap: $1.49B
EBITDA: $-158.80M
Book Value: $2.46
Earnings/Share: $-1.48
Profit Margin: 0.00%
Operating Margin: 0.00%
ROA (TTM): -38.79%
ROE (TTM): -63.26%
Revenue (TTM): $-665.00K
Revenue/Share (TTM): $-0.01
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): -99.60%

Stock Price History

1 Year Price History

2 Years Price History

5 Years Price History

10 Years Price History

Financial Charts

Revenue & Net Income (Yearly)

Revenue & Net Income (Quarterly)

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Earnings Per Share (EPS) History

Financial Ratios

Balance Sheet (Yearly)

Financial Ratios

Date Current Ratio Debt/Equity Debt/Assets Interest Coverage Debt/EBITDA
2025-12-31 14.27x 0.00x 0.08x N/A -0.01x
2024-12-31 6.67x 0.01x 0.15x N/A -0.01x
2023-12-31 5.66x 0.01x 0.16x N/A 0.06x
2022-12-31 8.20x 0.01x 0.13x -46.92x -0.01x
2021-12-31 6.03x 0.00x 2.43x -2,296.89x 0.00x
2020-12-31 1.86x -0.02x 5.73x -17.05x -0.04x
2019-12-31 0.71x -0.59x 8.87x -10.62x 13.40x

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