SLN
Silence Therapeutics PLC

SLN.US silence-therapeutics.com
Healthcare · Biotechnology
12.86
-0.16 (-1.23%)
USD · NASDAQ
52-week range
4.19
17.58
Trading at 65% of the 52-week range
Market Cap
809.25M
P/E Ratio
0.00
Forward P/E
0.00
Book Value
0.81
Div. Yield
N/A
% Institutions
39.68%
% Insiders
7.97%
1 Year

+166.8%
3 Year

+39.3%
10 Year

-33.2%
Description
Silence Therapeutics plc, a biotechnology company, engages in the discovery and development of novel molecules incorporating short interfering ribonucleic acid (siRNA) to inhibit the expression of specific target genes in hematology, cardiovascular, and rare diseases. The company develops Divesiran (SLN124), which is in Phase 2 development for polycythemia vera, and SLN548 for complement-mediated renal diseases. It also develops Zerlasiran (SLN360) for cardiovascular disease associated with elevated lipoprotein(a); SLN312 for dyslipidemia; SLN365 for hypercholesterolemia; and SLN098 for obesity. The company was formerly known as SR Pharma plc and changed its name to Silence Therapeutics plc in May 2007. Silence Therapeutics plc was incorporated in 1994 and is headquartered in London, United Kingdom.
People

▼
Directors & Officers

Name	Title	Year Born
Mr. Iain Gladstone Ross B.Sc., BSc (Hons), C.DIR, CH.D	Interim CEO & Chairman of the Board	1954
Ms. Rhonda L. Hellums	Executive VP, CFO, Secretary & Executive Director	1971
Dr. Steven J. Romano M.D.	Executive VP and Chief Research & Development Officer	1959
Dr. Marie Wikstrom Lindholm Ph.D.	Chief Scientific Officer	NA
Ms. Gem Gokmen Hopkins	Head of IR & Corporate Communications	NA
Mr. Jaimin B. Shah	SVP & General Counsel	NA
Mr. J.P. Gabriel	Chief Technical Operations Officer	NA
Mr. Curtis Rambaran M.D.	Chief Medical Officer	NA
Shareholders

▼
Institutional Holders

Holder Name	Shares	Date Reported	% Out	Value	% Change
TCG Crossover Management, LLC	3.03M	Jun 30, 2026	4.88%	$0.80	0.00%
Siren, L.L.C.	2.91M	Mar 31, 2026	4.68%	$0.43	0.00%
Redmile Group, LLC	2.16M	Jun 30, 2026	3.48%	$1.60	0.00%
Nantahala Capital Management, LLC	2.15M	Mar 31, 2026	3.45%	$0.42	39.18%
Citadel Advisors Llc	1.33M	Jun 30, 2026	2.14%	$0.00	7.68%
Nextech Invest, Ltd.	952.40K	Jun 30, 2026	1.53%	$0.50	0.00%
Millennium Management LLC	909.28K	Jun 30, 2026	1.46%	$0.00	-15.35%
Ikarian Capital, LLC	865.78K	Mar 31, 2026	1.39%	$0.14	0.00%
Polygon Management Ltd	764.26K	Jun 30, 2026	1.23%	$1.32	21.28%
Soleus Capital Management, L.P.	630.00K	Jun 30, 2026	1.01%	$0.24	0.00%
5AM Venture Management, LLC	476.20K	Jun 30, 2026	0.77%	$1.82	0.00%
Great Point Partners LLC	450.00K	Jun 30, 2026	0.72%	$0.93	-55.90%
SG Americas Securities, LLC	286.70K	Mar 31, 2026	0.46%	$0.00	11.84%
UBS Group AG	246.94K	Mar 31, 2026	0.40%	$0.00	19.00%
BOOTHBAY FUND MANAGEMENT, LLC	209.09K	Mar 31, 2026	0.34%	$0.01	0.00%
BlackRock Inc	204.78K	Mar 31, 2026	0.33%	$0.00	179.93%
BMO Capital Markets Corp.	202.90K	Mar 31, 2026	0.33%	$0.00	26.44%
Bank of Montreal	201.73K	Jun 30, 2026	0.32%	$0.00	-0.58%
Propel Bio Management LLC	191.73K	Jun 30, 2026	0.31%	$1.10	0.00%
ADAR1 Capital Management LLC	172.16K	Mar 31, 2026	0.28%	$0.05	628.15%
Fund Holdings

Rank	Holder Name	Shares Held	% of Shares	Change	Date Reported
1	International Biotechnology Ord	729.62K	1.17%	▲ 0.00%	May 31, 2026
2	MEDICAL BioHealth EUR Acc	543.63K	0.87%	▲ 0.09%	Jul 31, 2026
3	Fidelity Advisor Biotechnology I	482.09K	0.78%	▲ 0.00%	Jul 31, 2026
4	apo Medical Opportunities R	245.19K	0.39%	▲ 0.00%	Jul 31, 2026
5	iShares Biotechnology ETF	234.01K	0.38%	▲ 20.19%	Aug 31, 2026
6	Alger Life Sciences Innovation Composite	114.95K	0.18%	▲ 0.00%	Jun 30, 2026
7	Fidelity Select Biotechnology	103.91K	0.17%	▲ 0.00%	Jul 31, 2026
8	RIM Global Bioscience EUR	101.06K	0.16%	▲ 0.00%	May 31, 2026
9	Galileo - Biotech Innovation Fund S USD	58.65K	0.09%	▲ 0.00%	Feb 28, 2026
10	WEALTHGATE Biotech Fund Inst	38.33K	0.06%	▲ 0.00%	Jun 30, 2026
Financial Highlights

▼
Market Cap: $809.25M
EBITDA: $-63.94M
Book Value: $0.81
Earnings/Share: $-1.29
Profit Margin: 0.00%
Operating Margin: -10,475.61%
ROA (TTM): -29.65%
ROE (TTM): -90.41%
Revenue (TTM): $615.00K
Revenue/Share (TTM): $0.01
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): 197.20%
Valuation Metrics

Enterprise Value: $953.60M
Trailing P/E: 0.00
Forward P/E: 0.00
Shares Statistics

Shares Outstanding: 62.15M
Shares Float: 37.84M
% Insiders: 7.97%
% Institutions: 39.68%
Short % Float: 4.81%
Stock Price History

▼
1 Year Price History

3 Years Price History

10 Years Price History

Financial Charts

▼
Download Financials (Excel)
Revenue, Net Income & Operating Cash Flow (Yearly)

Revenue, Net Income & Operating Cash Flow (Quarterly)

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Income Statement Waterfall

▼
Line Item
Step Type
Value
Revenue
adjust
$559.00K
Cost of Goods Sold
adjust
$-215.00K
Gross Profit
subtotal
$344.00K
SG&A
adjust
$-22.34M
R&D
adjust
$-67.75M
Operating Income
subtotal
$-89.75M
Other / Non-Operating Items
adjust
$1.14M
Net Income
subtotal
$-88.61M
Earnings Per Share (EPS) History

▼
Financial Ratios

▼
📦 Raw API Data (JSON Explorer)

▼
Comprehensive raw data returned from the EOD Fundamentals API. Expand sections below to drill down.
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}
Silence Therapeutics PLC

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