Fundamentals - AlphaKey Financial

Name	Title	Year Born
Dr. Jeffrey T. Finer M.D., Ph.D.	Co-Founder, CEO & Director	1967
Ms. Elizabeth P. Bhatt M.B.A., M.S.	President & COO	1968
Mr. Gilbert M. Labrucherie C.F.A., J.D.	Chief Financial Officer	1972
Dr. Robert J. Lefkowitz M.D.	Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board	1944
Dr. Arthur Christopoulos BPHARM, Ph.D.	Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board	NA
Dr. Patrick Sexton Ph.D.	Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board	NA
Mr. Richard Hansen Ph.D.	Vice President of Technology	NA
Mr. Mark A. Wilson J.D.	Chief Legal Officer	1972
Mr. George Xu Ph.D.	Senior Director of Corporate Development & Portfolio Strategy	NA
Ms. Samira Shaikhly	Chief People Officer	1970
Date	Insider Name	Title	Transaction Type	Shares	Price	Value
Apr 15, 2026	Elizabeth Bhatt	N/A	Sale	4.00K	$24.34	$97.36K
Mar 02, 2026	Samira Shaikhly	N/A	Sale	70.45K	$28.10	$1.98M
Feb 18, 2026	Elizabeth Bhatt	N/A	Sale	4.00K	$28.97	$115.88K
Nov 10, 2025	Daniel D Long	N/A	Sale	3.50K	$18.06	$63.23K
Holder Name	Shares	Date Reported	% Out	Value	% Change
RA Capital Management, LLC	7.00M	Mar 31, 2026	15.52%	$1.78	0.00%
TRV GP V, LLC	6.22M	Mar 31, 2026	13.79%	$37.25	0.00%
Driehaus Capital Management LLC	4.40M	Mar 31, 2026	9.75%	$0.78	-8.61%
TRV GP VI, LLC	4.21M	Mar 31, 2026	9.34%	$74.64	0.00%
Samsara BioCapital, LLC	3.15M	Mar 31, 2026	6.99%	$7.35	0.00%
The Goldman Sachs Group Inc	2.91M	Mar 31, 2026	6.45%	$0.01	7.05%
Siren, L.L.C.	2.00M	Mar 31, 2026	4.44%	$1.33	0.00%
BlackRock Inc	1.82M	Mar 31, 2026	4.04%	$0.00	1.16%
Vanguard Group Inc	1.51M	Dec 31, 2025	3.35%	$0.00	-0.70%
Bvf Inc	1.35M	Mar 31, 2026	3.00%	$1.04	-21.36%
venBio Select Advisor LLC	1.34M	Mar 31, 2026	2.97%	$0.32	0.00%
Vanguard Capital Management, LLC	1.20M	Mar 31, 2026	2.66%	$0.00	0.00%
ADAR1 Capital Management LLC	1.09M	Mar 31, 2026	2.42%	$1.54	-5.86%
PRIMECAP Management Company	1.05M	Mar 31, 2026	2.33%	$0.02	92.06%
HHG PLC	890.75K	Mar 31, 2026	1.98%	$0.01	0.00%
First Light Asset Management, LLC	732.86K	Mar 31, 2026	1.63%	$1.58	18.05%
Geode Capital Management, LLC	645.15K	Mar 31, 2026	1.43%	$0.00	12.64%
State Street Corp	631.45K	Mar 31, 2026	1.40%	$0.00	16.93%
Casdin Capital, LLC	553.27K	Mar 31, 2026	1.23%	$1.01	0.00%
VR Adviser, LLC	506.06K	Mar 31, 2026	1.12%	$0.45	-17.15%
Fund Holdings

▼
Rank	Holder Name	Shares Held	% of Shares	Change	Date Reported
1	Vanguard Total Stock Mkt Idx Inv	906.67K	2.01%	▲ 0.00%	Apr 30, 2026
2	PRIMECAP Odyssey Aggressive Growth	749.68K	1.66%	▲ 75.45%	Mar 31, 2026
3	iShares Russell 2000 ETF	509.19K	1.13%	▲ 0.93%	May 29, 2026
4	Heptagon Driehaus US Micro Cap Eq C$ Acc	406.22K	0.90%	▲ 1.98%	Apr 30, 2026
5	Driehaus Small Cap Growth Institutional	394.94K	0.88%	▲ 4.75%	Apr 30, 2026
6	Heptagon Driehaus US Sm Cp Eq C USD Acc	363.25K	0.81%	▲ 0.55%	Apr 30, 2026
7	Vanguard Institutional Extnd Mkt Idx Tr	260.63K	0.58%	▲ 0.54%	Apr 30, 2026
8	Fidelity Small Cap Index	210.04K	0.47%	▲ 0.31%	Mar 31, 2026
9	iShares Biotechnology ETF	199.55K	0.44%	▲ 1.95%	May 29, 2026
10	iShares Russell 2000 Value ETF	184.43K	0.41%	▲ 0.00%	May 29, 2026
Valuation Metrics

▼
Enterprise Value: $1.30B
Trailing P/E: 0.00
Forward P/E: 107.53
Financial Highlights

▼
Market Cap: $1.62B
EBITDA: $-66.56M
Book Value: $8.52
Earnings/Share: $-0.80
Profit Margin: -49.88%
Operating Margin: -50.15%
ROA (TTM): -8.49%
ROE (TTM): -9.26%
Revenue (TTM): $72.26M
Revenue/Share (TTM): $1.63
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): 12,011.00%
Stock Price History

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1 Year Price History

2 Years Price History

5 Years Price History

10 Years Price History

Financial Charts

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Download Financials (Excel)
Revenue & Net Income (Yearly)

Revenue & Net Income (Quarterly)

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Earnings Per Share (EPS) History

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Financial Ratios

▼
Balance Sheet (Yearly)

▼
Date	Cash	Total Debt	Total Assets	Total Liabilities	Total Equity
2025-12-31	$120.72M	$N/A	$596.19M	$214.26M	$381.93M
2024-12-31	$238.20M	$N/A	$456.55M	$36.51M	$420.05M
2023-12-31	$88.48M	$N/A	$130.87M	$169.24M	$-38.37M
2022-12-31	$30.61M	$N/A	$36.12M	$80.32M	$-44.20M
Financial Ratios

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Date	Current Ratio	Debt/Equity	Debt/Assets	Interest Coverage	Debt/EBITDA
2025-12-31	4.73x	0.01x	0.36x	N/A	-0.05x
2024-12-31	27.77x	0.00x	0.08x	N/A	-0.03x
2023-12-31	16.30x	0.00x	1.29x	N/A	0.00x
2022-12-31	5.75x	-0.02x	2.22x	N/A	-0.03x
📦 Raw API Data (JSON Explorer)

▼
Comprehensive raw data returned from the EOD Fundamentals API. Expand sections below to drill down.
{
    "General": {
        "Code": "SEPN",
        "Type": "Common Stock",
        "Name": "Septerna, Inc. Common Stock",
        "Exchange": "NASDAQ",
        "CurrencyCode": "USD",
        "CurrencyName": "US Dollar",
        "CurrencySymbol": "$",
        "CountryName": "USA",
        "CountryISO": "US",
        "OpenFigi": "BBG014WY1V28",
        "ISIN": "US81734D1046",
        "LEI": null,
        "PrimaryTicker": "SEPN.US",
        "CUSIP": null,
        "CIK": null,
        "EmployerIdNumber": null,
        "FiscalYearEnd": "December",
        "IPODate": "2024-10-25",
        "InternationalDomestic": null,
        "Sector": "Healthcare",
        "Industry": "Biotechnology",
        "GicSector": "Health Care",
        "GicGroup": "Pharmaceuticals, Biotechnology & Life Sciences",
        "GicIndustry": "Pharmaceuticals",
        "GicSubIndustry": "Pharmaceuticals",
        "HomeCategory": null,
        "IsDelisted": false,
        "Description": "Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves' disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women's health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.",
        "Address": "250 East Grand Avenue, South San Francisco, CA, United States, 94080",
        "AddressData": {
            "Street": "250 East Grand Avenue",
            "City": "South San Francisco",
            "State": "CA",
            "Country": "United States",
            "ZIP": "94080"
        },
        "Listings": [],
        "Officers": [
            {
                "Name": "Dr. Jeffrey T. Finer M.D., Ph.D.",
                "Title": "Co-Founder, CEO & Director",
                "YearBorn": "1967"
            },
            {
                "Name": "Ms. Elizabeth P. Bhatt M.B.A., M.S.",
                "Title": "President & COO",
                "YearBorn": "1968"
            },
            {
                "Name": "Mr. Gilbert M. Labrucherie C.F.A., J.D.",
                "Title": "Chief Financial Officer",
                "YearBorn": "1972"
            },
            {
                "Name": "Dr. Robert J. Lefkowitz M.D.",
                "Title": "Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board",
                "YearBorn": "1944"
            },
            {
                "Name": "Dr. Arthur  Christopoulos BPHARM, Ph.D.",
                "Title": "Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board",
                "YearBorn": "NA"
            },
            {
                "Name": "Dr. Patrick  Sexton Ph.D.",
                "Title": "Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board",
                "YearBorn": "NA"
            },
            {
                "Name": "Mr. Richard  Hansen Ph.D.",
                "Title": "Vice President of Technology",
                "YearBorn": "NA"
            },
            {
                "Name": "Mr. Mark A. Wilson J.D.",
                "Title": "Chief Legal Officer",
                "YearBorn": "1972"
            },
            {
                "Name": "Mr. George  Xu Ph.D.",
                "Title": "Senior Director of Corporate Development & Portfolio Strategy",
                "YearBorn": "NA"
            },
            {
                "Name": "Ms. Samira  Shaikhly",
                "Title": "Chief People Officer",
                "YearBorn": "1970"
            }
        ],
        "Phone": "650 338 3533",
        "WebURL": "https://septerna.com",
        "LogoURL": "/img/logos/US/SEPN.png",
        "FullTimeEmployees": 130,
        "UpdatedAt": "2026-06-16"
    },
    "Highlights": {
        "MarketCapitalization": 1624071424,
        "MarketCapitalizationMln": 1624.0714,
        "EBITDA": -66559000,
        "PERatio": null,
        "PEGRatio": null,
        "WallStreetTargetPrice": 45.7778,
        "BookValue": 8.524,
        "DividendShare": null,
        "DividendYield": null,
        "EarningsShare": -0.8,
        "EPSEstimateCurrentYear": -1.839,
        "EPSEstimateNextYear": -2.6592,
        "EPSEstimateNextQuarter": -0.1731,
        "EPSEstimateCurrentQuarter": -0.2744,
        "MostRecentQuarter": "2026-03-31",
        "ProfitMargin": -0.4988,
        "OperatingMarginTTM": -0.5015,
        "ReturnOnAssetsTTM": -0.0849,
        "ReturnOnEquityTTM": -0.0926,
        "RevenueTTM": 72255000,
        "RevenuePerShareTTM": 1.625,
        "QuarterlyRevenueGrowthYOY": 120.11,
        "GrossProfitTTM": 72255000,
        "DilutedEpsTTM": -0.8,
        "QuarterlyEarningsGrowthYOY": 0
    },
    "Valuation": {
        "TrailingPE": 0,
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        "PriceSalesTTM": 22.4769,
        "PriceBookMRQ": 4.2972,
        "EnterpriseValue": 1302014230,
        "EnterpriseValueRevenue": 18.0197,
        "EnterpriseValueEbitda": 0
    },
    "SharesStats": {
        "SharesOutstanding": 45075533,
        "SharesFloat": 23120593,
        "PercentInsiders": 3.175,
        "PercentInstitutions": 102.635,
        "SharesShort": null,
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        "ShortRatio": null,
        "ShortPercentOutstanding": null,
        "ShortPercentFloat": 0.1147
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    "Technicals": {
        "Beta": null,
        "52WeekHigh": 37.01,
        "52WeekLow": 9.96,
        "50DayMA": 27.0905,
        "200DayMA": 24.42,
        "SharesShort": 2617322,
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        "ShortRatio": 8.59,
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    },
    "SplitsDividends": {
        "ForwardAnnualDividendRate": 0,
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        "PayoutRatio": 0,
        "DividendDate": null,
        "ExDividendDate": null,
        "LastSplitFactor": null,
        "LastSplitDate": null,
        "NumberDividendsByYear": []
    },
    "AnalystRatings": {
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        "StrongBuy": 2,
        "Buy": 1,
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        "StrongSell": 0
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    "Holders": {
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                "name": "Bvf Inc",
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            {
                "name": "venBio Select Advisor LLC",
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            {
                "name": "HHG PLC",
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                "name": "Geode Capital Management, LLC",
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                "name": "Vanguard Institutional Extnd Mkt Idx Tr",
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                "change_p": 0.5424
            },
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                "name": "Fidelity Small Cap Index",
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            },
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                "change_p": 0
            },
            {
                "name": "Driehaus Micro Cap Growth USD",
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                "change_p": 0.8065
            },
            {
                "name": "State Street\u00ae SPDR\u00ae S&P\u00ae PhrmctlsETF",
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                "currentShares": 139303,
                "change": 0,
                "change_p": 0
            },
            {
                "name": "Russell 2000 Equity Index Fund B",
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                "change": -68,
                "change_p": -0.0494
            },
            {
                "name": "State St Russell Sm/Mid Cp\u00ae Indx SL Cl I",
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                "change": 50400,
                "change_p": 59.5745
            },
            {
                "name": "Fidelity Extended Market Index",
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                "name": "Column Small Cap Select",
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            {
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}
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