Stock Fundamentals

Company Information

Company Name
Prelude Therapeutics Inc
Sector
Healthcare
Industry
Biotechnology
Exchange
NASDAQ
ISIN: US74065P1012
CIK: 0001678660
CUSIP: 74065P101
Currency: USD
Full Time Employees: 131
Phone: 302 467 1280
Fiscal Year End: December
IPO Date: Sep 25, 2020
Description:

Prelude Therapeutics Incorporated, a clinical-stage precision oncology company, focuses on the discovery and development of novel precision cancer medicines to underserved patients. It is developing PRT3789, a selective degrader of SMARCA2 protein for the treatment of advanced or metastatic solid tumors with loss of SMARCA4 due to truncating mutation and/or deletion; PRT7732, a selective and orally bioavailable SMARCA2 degraders to treat advanced or metastatic solid tumors; and PRT2527, a cyclin-dependent kinase 9 inhibitor for the treatment of advanced solid tumors. The company's CDK9 program is a regulator of cancer-promoting transcriptional programs, including MCL1, MYC, and MYB. Prelude Therapeutics Incorporated was incorporated in 2016 and is based in Wilmington, Delaware.

Address:

175 Innovation Boulevard, Wilmington, DE, United States, 19805

Directors & Officers

Name Title Year Born
Dr. Krishna Vaddi D.V.M., Ph.D. Founder, CEO & Director 1966
Mr. Bryant David Lim J.D. CFO & Chief Legal Officer 1972
Ms. Aimee Crombie Ph.D. Senior VP and Head of Strategic Planning & Operations NA
Dr. Madhu Pudipeddi Ph.D. Senior Vice President of Technical Operations NA
Dr. Peggy A. Scherle Ph.D. Chief Scientific Officer 1962
Mr. Robert A. Doody Jr. Senior Vice President of Investor Relations NA
Ms. Michele Porreca M.B.A. Chief People Officer NA
Dr. Andrew P. Combs Ph.D. Executive VP & Chief Chemistry Officer 1967
Mr. Naveen Babbar Ph.D. Senior Vice President of Translation Medicine NA
Dr. Wan-Jen Hong M.D. Senior Vice President of Clinical Development 1979

Institutional Holders

Holder Name Shares Date Reported % Out Value % Change
Orbimed Advisors, LLC 10.91M Sep 30, 2025 17.35% $0.37 0.00%
Baker Bros Advisors LP 10.12M Dec 31, 2025 16.10% $0.17 0.00%
Vanguard Group Inc 1.41M Dec 31, 2025 2.25% $0.00 42.42%
Millennium Management LLC 1.15M Sep 30, 2025 1.82% $0.00 361.73%
T. Rowe Price Associates, Inc. 876.34K Sep 30, 2025 1.39% $0.00 -5.53%
Kynam Capital Management, LP 788.87K Dec 31, 2025 1.25% $0.15 0.00%
Two Sigma Investments LLC 788.70K Dec 31, 2025 1.25% $0.00 418.08%
Acadian Asset Management LLC 540.57K Sep 30, 2025 0.86% $0.00 0.00%
Morgan Stanley - Brokerage Accounts 284.20K Sep 30, 2025 0.45% $0.00 -0.06%
Renaissance Technologies Corp 271.30K Dec 31, 2025 0.43% $0.00 -50.13%
BlackRock Inc 264.97K Sep 30, 2025 0.42% $0.00 -38.74%
Two Sigma Advisers, LLC 237.30K Dec 31, 2025 0.38% $0.00 6.56%
Geode Capital Management, LLC 217.57K Sep 30, 2025 0.35% $0.00 0.00%
TD Asset Management Inc 160.65K Dec 31, 2025 0.26% $0.00 0.00%
Sphera Funds Management Ltd. 122.75K Dec 31, 2025 0.20% $0.07 0.00%
State Street Corp 97.59K Sep 30, 2025 0.16% $0.00 0.00%
The Goldman Sachs Group Inc 79.33K Sep 30, 2025 0.13% $0.00 -46.82%
Omers Administration Corp 73.00K Dec 31, 2025 0.12% $0.00 0.00%
Manufacturers Life Insurance Co 70.55K Dec 31, 2025 0.11% $0.00 1.87%
Bridgeway Capital Management, LLC 53.50K Dec 31, 2025 0.09% $0.00 0.00%

Shares Statistics

Shares Outstanding: 43.77M
Shares Float: 16.40M
% Insiders: 993.40%
% Institutions: 5,710.30%
Short % Float: 31.57%

🏆 Top 10 Institutional Holders

Rank Holder Name Shares Held % of Shares Change Date Reported
1 Orbimed Advisors, LLC 10.91M 17.35% ▲ 0.00% Sep 30, 2025
2 Baker Bros Advisors LP 10.12M 16.10% ▲ 0.00% Dec 31, 2025
3 Vanguard Group Inc 1.41M 2.25% ▲ 42.42% Dec 31, 2025
4 Millennium Management LLC 1.15M 1.82% ▲ 361.73% Sep 30, 2025
5 T. Rowe Price Associates, Inc. 876.34K 1.39% ▼ 5.53% Sep 30, 2025
6 Kynam Capital Management, LP 788.87K 1.25% ▲ 0.00% Dec 31, 2025
7 Two Sigma Investments LLC 788.70K 1.25% ▲ 418.08% Dec 31, 2025
8 Acadian Asset Management LLC 540.57K 0.86% ▲ 0.00% Sep 30, 2025
9 Morgan Stanley - Brokerage Accounts 284.20K 0.45% ▼ 0.06% Sep 30, 2025
10 Renaissance Technologies Corp 271.30K 0.43% ▼ 50.13% Dec 31, 2025

Valuation Metrics

Enterprise Value: $137.03M
Trailing P/E: 0.00
Forward P/E: 0.00

Financial Highlights

Market Cap: $173.51M
EBITDA: $-119.27M
Book Value: $0.77
Earnings/Share: $-1.47
Profit Margin: 0.00%
Operating Margin: -314.12%
ROA (TTM): -51.82%
ROE (TTM): -103.99%
Revenue (TTM): $10.50M
Revenue/Share (TTM): $0.14
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): 116.70%

Stock Price History

1 Year Price History

2 Years Price History

5 Years Price History

10 Years Price History

Download Financials (Excel)

Financial Charts

Revenue & Net Income (Yearly)

Revenue & Net Income (Quarterly)

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Earnings Per Share (EPS) History

Financial Ratios (Yearly)

Financial Ratios (Quarterly)

Earnings History

Balance Sheet (Yearly)

Financial Ratios

Date Current Ratio Debt/Equity Debt/Assets Interest Coverage Debt/EBITDA
2024-12-31 5.30x 0.02x 0.25x N/A -0.02x
2023-12-31 10.79x 0.01x 0.15x N/A -0.01x
2022-12-31 9.42x 0.01x 0.11x -93.31x -0.01x
2021-12-31 15.37x 0.01x 0.06x -55.73x -0.02x
2020-12-31 19.41x 0.00x 0.05x N/A 0.00x
2019-12-31 4.18x -0.01x 3.26x N/A -0.01x
2018-12-31 6.37x 0.00x 2.38x N/A 0.00x

Insider Trading

Date Insider Name Title Transaction Type Shares Price Value
Mar 25, 2025 Andrew Combs N/A Purchase 100.00K $0.69 $69.00K
Mar 25, 2025 Krishna Vaddi N/A Purchase 675.00K $0.69 $465.75K
Mar 12, 2025 Krishna Vaddi N/A Purchase 47.50K $0.71 $33.73K

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