GYRE
Gyre Therapeutics Inc.

GYRE.US gyretx.com + Research + Basket
Healthcare · Biotechnology
CIK 0001124105
Employees 625
Phone 858-284-0115
Fiscal year end December
IPO Apr 12, 2006
Address 12730 High Bluff Drive, San Diego, CA, United States, 92130
6.83
+0.30 (+4.59%)
USD · NASDAQ
52-week range
5.44
9.14
Trading at 38% of the 52-week range
Market Cap
692.40M
P/E Ratio
0.00
Forward P/E
188.68
Book Value
1.02
Div. Yield
N/A
% Institutions
8.24%
% Insiders
74.40%
1 Year

-18.6%
3 Year

-14.6%
10 Year

-93.5%
Description
Gyre Therapeutics, Inc., a pharmaceutical company, engages in the development and commercialization of small-molecule, anti-inflammatory, and anti-fibrotic drugs targeting organ fibrosis. The company offers ETUARY (Pirfenidone), an anti-fibrotic drug approved for the treatment of idiopathic pulmonary fibrosis; and under Phase 3 trials for the treatment of pneumoconiosis. It is also involved in the development of F351 (Hydronidone), a structural derivative of ETUARY under Phase 3 trials for the treatment of chronic hepatitis B (CHB)-associated liver fibrosis; and completed Phase 1 trials for the treatment of liver fibrosis associated with metabolic dysfunction-associated steatohepatitis. In addition, the company develops F573, which is in Phase 2 clinical trials for the treatment of acute/acute-on-chronic liver failure. Further, its preclinical products include F230 for the treatment of pulmonary arterial hypertension; and F528 to treat chronic obstructive pulmonary disease. Gyre Therapeutics, Inc. was founded in 2002 and is headquartered in San Diego, California. Gyre Therapeutics, Inc. operates as a subsidiary of GNI USA, Inc.
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People

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Directors & Officers

Name	Title	Year Born
Mr. Thomas W. Eastling M.D.	Chief Financial Officer	1959
Mr. Weiguo Ye	Chief Operating Officer	1978
Ms. Ruoyu Chen	Chief Information Officer	1971
Dr. Ying Luo Ph.D.	CEO, President & Director	1965
Dr. Yue Xiong Ph.D.	Chief Scientific Officer & Director	NA
Mr. Joshua Bergmann J.D.	General Counsel & Corporate Secretary	NA
Seth Goldblum M.B.A.	Senior Vice President of Corporate Development	NA
Mr. Jialiang Wang Ph.D.	Executive VP & GM	NA
Jing Liu Ph.D.	Senior Vice President of Platform Chemistry	NA
Mark Marino	Senior Vice President of Clinical Development	NA
Insider Trading

Open insider trading
Date	Insider Name	Title	Transaction Type	Shares	Price	Value	SEC
May 23, 2025	Songjiang Ma	N/A	Sale	182.00	$10.24	$1.86K	SEC
May 22, 2025	Songjiang Ma	N/A	Sale	2.00K	$10.97	$21.94K	SEC
Shareholders

▼
Institutional Holders

Holder Name	Shares	Date Reported	% Out	Value	% Change
HSG Holding Ltd	3.75M	Jun 30, 2026	3.54%	$2.06	0.00%
BlackRock Inc	993.94K	Jun 30, 2026	0.94%	$0.00	31.02%
Octagon Capital Advisors LP	954.42K	Jun 30, 2026	0.90%	$0.57	0.00%
Vanguard Capital Management, LLC	876.93K	Jun 30, 2026	0.83%	$0.00	-10.90%
Geode Capital Management, LLC	532.95K	Jun 30, 2026	0.50%	$0.00	23.54%
State Street Corp	245.40K	Jun 30, 2026	0.23%	$0.00	13.44%
Charles Schwab Investment Management Inc	184.29K	Jun 30, 2026	0.17%	$0.00	11.53%
Northern Trust Corp	169.54K	Jun 30, 2026	0.16%	$0.00	26.67%
SBI Securities Co Ltd	166.75K	Jun 30, 2026	0.16%	$0.03	-2.39%
Vanguard Fiduciary Trust Co	151.07K	Jun 30, 2026	0.14%	$0.00	9.73%
Vanguard Portfolio Management, LLC	123.95K	Jun 30, 2026	0.12%	$0.00	77.55%
The Goldman Sachs Group Inc	86.24K	Jun 30, 2026	0.08%	$0.00	17.93%
Bank of New York Mellon Corp	62.75K	Jun 30, 2026	0.06%	$0.00	45.44%
Morgan Stanley - Brokerage Accounts	41.69K	Jun 30, 2026	0.04%	$0.00	382.48%
STRS OHIO	25.80K	Jun 30, 2026	0.02%	$0.00	22.27%
Dimensional Fund Advisors, Inc.	25.27K	Jun 30, 2026	0.02%	$0.00	0.00%
AllianceBernstein L.P.	24.59K	Jun 30, 2026	0.02%	$0.00	12.64%
Nuveen, LLC	24.51K	Jun 30, 2026	0.02%	$0.00	0.00%
UBS Group AG	18.76K	Jun 30, 2026	0.02%	$0.00	-11.02%
Millennium Management LLC	18.49K	Jun 30, 2026	0.02%	$0.00	0.00%
Fund Holdings

Rank	Holder Name	Shares Held	% of Shares	Change	Date Reported
1	Vanguard MStar Total Stk Mkt Idx Invest	1.04M	0.98%	▲ 69.64%	Sep 30, 2026
2	iShares Russell 2000 ETF	396.32K	0.37%	▼ 1.13%	Sep 30, 2026
3	Fidelity Small Cap Index	199.91K	0.19%	▼ 0.12%	Jul 31, 2026
4	Schwab US Small-Cap ETF™	184.52K	0.17%	▲ 0.06%	Sep 30, 2026
5	Fidelity Extended Market Index	110.28K	0.10%	▼ 0.53%	Aug 31, 2026
6	iShares Russell 2000 Growth ETF	100.60K	0.09%	▼ 0.13%	Sep 30, 2026
7	Vanguard Russell 2000 ETF	90.61K	0.09%	▼ 14.32%	Sep 30, 2026
8	Fidelity Nasdaq Composite Index	62.21K	0.06%	▲ 0.00%	Aug 31, 2026
9	Multimanager Aggressive Equity IA	43.20K	0.04%	▲ 0.00%	Aug 31, 2026
10	iShares Russell 2000 Value ETF	41.89K	0.04%	▲ 0.15%	Sep 30, 2026
Financial Highlights

▼
Market Cap: $692.40M
EBITDA: $-12.13M
Book Value: $1.02
Earnings/Share: $-0.25
Profit Margin: -19.33%
Operating Margin: -47.62%
ROA (TTM): -5.42%
ROE (TTM): -17.44%
Revenue (TTM): $109.82M
Revenue/Share (TTM): $1.17
Earnings Growth (YOY): 166.20%
Revenue Growth (YOY): -2.10%
Valuation Metrics

Enterprise Value: $573.31M
Trailing P/E: 0.00
Forward P/E: 188.68
Shares Statistics

Shares Outstanding: 106.03M
Shares Float: 35.94M
% Insiders: 74.40%
% Institutions: 8.24%
Short % Float: 6.45%
Stock Price History

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1 Year Price History

3 Years Price History

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Financial Charts

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Open balance sheet Open capital intensity Download Financials (Excel)
Revenue, Net Income & Operating Cash Flow (Yearly)

Change % vs Prior Year

Revenue, Net Income & Operating Cash Flow (Quarterly)

Change % vs Prior Quarter

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Income Statement Waterfall

▼
Line Item
Step Type
Value
Revenue
adjust
$116.59M
Cost of Goods Sold
adjust
$-5.42M
Gross Profit
subtotal
$111.17M
SG&A
adjust
$-20.80M
R&D
adjust
$-13.70M
Other Operating Expense
adjust
$-65.18M
Operating Income
subtotal
$11.49M
Other / Non-Operating Items
adjust
$-6.46M
Net Income
subtotal
$5.03M
Earnings Per Share (EPS) History

▼
Financial Ratios

▼
📦 Raw API Data (JSON Explorer)

▼
Comprehensive raw data returned from the EOD Fundamentals API. Expand sections below to drill down.
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}
Gyre Therapeutics Inc.

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