Fulcrum Therapeutics Inc

FULC.US
Healthcare · Biotechnology
3.72
-0.01 (-0.27%)
USD · NASDAQ

Company Information

Company Name
Fulcrum Therapeutics Inc
Sector
Healthcare
Industry
Biotechnology
Exchange
NASDAQ
ISIN: US3596161097
CIK: 0001680581
CUSIP: 359616109
Currency: USD
Full Time Employees: 55
Phone: 617 651 8851
Fiscal Year End: December
IPO Date: Jul 18, 2019
Description:

Fulcrum Therapeutics, Inc., a clinical-stage biopharmaceutical company, develops small molecules to improve the lives of patients with genetically defined diseases in the areas of high unmet medical need in the United States. Its clinical-stage product candidate is pociredir, a fetal hemoglobin inducer, which is in phase 1b clinical trial for the treatment of sickle cell disease and beta-thalassemia. The company also discovers programs for the treatment of diamond-blackfan anemia, Bone Marrow Failure Syndromes, novel fetal hemoglobin inducers, fibrotic disorders. It has licensce agreement with CAMP4 which includes certain small molecule compounds, composition of matter and method of use patent rights, and know-how to research, develop, manufacture, use, and commercialize. Fulcrum Therapeutics, Inc. was Incorporated in 2015 and is headquartered in Cambridge, Massachusetts.

Address:

26 Landsdowne Street, Cambridge, MA, United States, 02139

People

Directors & Officers

Name Title Year Born
Mr. Alexander C. Sapir CEO, President & Director 1967
Mr. Curtis G. Oltmans J.D. Chief Legal Officer, Head of External Affairs & Corporate Secretary 1963
Dr. Bradley E. Bernstein M.D., Ph.D. Founder NA
Dr. Michael R. Green Founder NA
Dr. Rudolf Jaenisch M.D., Ph.D. Founder NA
Dr. Tsun-Huei Lee M.D., Ph.D. Founder 1964
Dr. Danny Reinberg Founder NA

Insider Trading

Date Insider Name Title Transaction Type Shares Price Value
Jan 02, 2026 Robert J Gould N/A Sale 15.00K $11.87 $178.05K
Dec 08, 2025 Ra Capital Management, L.P. N/A Sale 4.18M $13.98 $58.37M
Nov 19, 2025 Robert J Gould N/A Sale 15.00K $11.03 $165.45K
May 08, 2025 Greg Tourangeau N/A Sale 498.00 $5.06 $2.52K

Shareholders

Institutional Holders

Holder Name Shares Date Reported % Out Value % Change
Suvretta Capital Management, LLC 6.56M Mar 31, 2026 9.85% $1.29 0.00%
RA Capital Management, LLC 6.05M Mar 31, 2026 9.09% $0.49 0.00%
BlackRock Inc 5.39M Mar 31, 2026 8.09% $0.00 26.43%
TCG Crossover Management, LLC 5.25M Mar 31, 2026 7.88% $1.15 0.00%
Vanguard Group Inc 3.56M Dec 31, 2025 5.34% $0.00 18.67%
BRAIDWELL LP 3.13M Mar 31, 2026 4.70% $0.80 2.41%
Nantahala Capital Management, LLC 3.05M Mar 31, 2026 4.58% $0.86 -28.96%
Vanguard Capital Management, LLC 2.69M Mar 31, 2026 4.04% $0.00 0.00%
Siren, L.L.C. 2.35M Mar 31, 2026 3.53% $0.50 20.51%
First Turn Management LLC 2.26M Mar 31, 2026 3.39% $1.93 19.20%
Aberdeen Group PLC 2.21M Mar 31, 2026 3.32% $0.03 76.39%
Point72 Asset Management, L.P. 2.07M Mar 31, 2026 3.11% $0.02 -13.48%
GSK PLC 1.79M Mar 31, 2026 2.68% $2.29 0.00%
Balyasny Asset Management LLC 1.78M Mar 31, 2026 2.67% $0.02 83.42%
Jones Hill Capital LP 1.77M Mar 31, 2026 2.66% $2.91 0.00%
D. E. Shaw & Co LP 1.62M Mar 31, 2026 2.44% $0.01 -15.18%
State Street Corp 1.55M Mar 31, 2026 2.33% $0.00 54.16%
Geode Capital Management, LLC 1.49M Mar 31, 2026 2.23% $0.00 34.43%
Alyeska Investment Group, L.P. 1.33M Mar 31, 2026 1.99% $0.03 0.00%
Citadel Advisors Llc 1.29M Mar 31, 2026 1.94% $0.00 7.08%

Fund Holdings

Rank Holder Name Shares Held % of Shares Change Date Reported
1 Vanguard Total Stock Mkt Idx Inv 2.07M 3.11% ▲ 0.00% Jun 30, 2026
2 iShares Russell 2000 ETF 1.56M 2.34% ▲ 0.60% Jun 30, 2026
3 BlackRock Advantage Small Cap Core Instl 1.32M 1.99% ▲ 217.55% Jun 30, 2026
4 State Street® SPDR® S&P® PhrmctlsETF 807.59K 1.21% ▲ 5.74% Jun 30, 2026
5 Fidelity Small Cap Index 592.87K 0.89% ▲ 0.86% Apr 30, 2026
6 iShares Russell 2000 Value ETF 563.94K 0.85% ▼ 0.68% Jun 30, 2026
7 Vanguard Institutional Extnd Mkt Idx Tr 553.38K 0.83% ▲ 0.09% Jun 30, 2026
8 iShares Biotechnology ETF 402.23K 0.60% ▲ 1.05% Jun 30, 2026
9 Russell 2000 Equity Index Fund B 377.20K 0.57% ▼ 0.19% Jun 30, 2026
10 Russell 2000 Index Non-Lendable Fund 377.20K 0.57% ▼ 0.19% Jun 30, 2026

Financial Highlights

Market Cap: $248.54M
EBITDA: $-85.18M
Book Value: $5.00
Earnings/Share: $-1.15
Profit Margin: 0.00%
Operating Margin: 0.00%
ROA (TTM): -18.36%
ROE (TTM): -27.10%
Revenue (TTM): $0.00
Revenue/Share (TTM): $0.00
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): -100.00%

Valuation Metrics

Enterprise Value: $-79.57M
Trailing P/E: 0.00
Forward P/E: 0.00

Shares Statistics

Shares Outstanding: 66.63M
Shares Float: 41.99M
% Insiders: 383.20%
% Institutions: 13,357.30%
Short % Float: 10.50%

Stock Price History

1 Year Price History

2 Years Price History

5 Years Price History

10 Years Price History

Financial Charts

Revenue & Net Income (Yearly)

Revenue & Net Income (Quarterly)

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Income Statement Waterfall

Open full waterfall
Line Item
Step Type
Value
Revenue
adjust
$0.00
Cost of Goods Sold
adjust
$-1.39M
Gross Profit
subtotal
$-1.39M
SG&A
adjust
$-28.67M
R&D
adjust
$-56.10M
Operating Income
subtotal
$-84.77M
Other / Non-Operating Items
adjust
$9.89M
Net Income
subtotal
$-74.88M

Earnings Per Share (EPS) History

Financial Ratios

📦 Raw API Data (JSON Explorer)

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