ENSC
Ensysce Biosciences Inc

ENSC.US ensysce.com + Research + Basket
Healthcare · Biotechnology
CIK 0001716947
Employees 8
Phone 858 263 4196
Fiscal year end December
IPO Feb 26, 2018
Address 7946 Ivanhoe Avenue, La Jolla, CA, United States, 92037
0.47
+0.02 (+4.47%)
USD · NASDAQ
52-week range
0.23
2.23
Trading at 12% of the 52-week range
Market Cap
8.75M
P/E Ratio
0.00
Forward P/E
0.95
Book Value
-0.05
Div. Yield
N/A
% Institutions
4.65%
% Insiders
4.72%
1 Year

-79.0%
3 Year

-96.7%
10 Year

-100.0%
Description
Ensysce Biosciences, Inc., a clinical-stage pharmaceutical company, develops prescription drugs for severe pain relief in opioid misuse, abuse, and overdose in the United States. It develops products using Trypsin Activated Abuse Protection (TAAP) platform, designed to release clinically effective drugs only when exposed to specific physiological conditions; and Multi-Pill Abuse Resistance (MPAR) platform, an over-dose protection opioid prodrug technology. The company's lead product candidate is PF614, a TAAP oxycodone prodrug candidate for the treatment of severe or chronic pain; and PF614-MPAR, a combination product of PF614 and nafamostat for overdose protection. It is also developing PF8001 and PF8026 are extended and immediate-release prodrugs of amphetamine for attention deficit hyperactivity disorder; and PF9001 to treat opioid use disorder. Further, It develops neuroplastogenic therapies and psychedelic-derived molecules for severe chronic pain, particularly complex regional pain syndrome (CRPS). Ensysce Biosciences, Inc. was founded in 2003 and is based in La Jolla, California.
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People

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Directors & Officers

Name	Title	Year Born
Dr. D. Lynn Kirkpatrick Ph.D.	CEO & Director	1957
Mr. David C. Humphrey CPA	CFO, Secretary & Treasurer	1969
Mr. Geoffrey Birkett	Chief Commercial Officer	1963
Mr. James Morrison	President & Director	NA
Dr. William K. Schmidt Ph.D.	Chairman of Clinical Advisory Board & Chief Medical Officer	1951
Dr. Linda Pestano Ph.D.	Chief Development Officer	1969
Mr. Richard Langford	Chief Medical Officer of Cy Biopharma	NA
Insider Trading

Open insider trading
Date	Insider Name	Title	Transaction Type	Shares	Price	Value	SEC
Mar 02, 2023	Bob G Gower	N/A	Purchase	501.00	$88.20	$44.19K	SEC
Shareholders

▼
Institutional Holders

Holder Name	Shares	Date Reported	% Out	Value	% Change
Jane Street Group LLC	208.83K	Jun 30, 2026	1.07%	$0.00	1,438.93%
Adage Capital Partners Gp LLC	149.71K	Jun 30, 2026	0.77%	$0.00	0.00%
Virtu Financial LLC	95.39K	Jun 30, 2026	0.49%	$0.00	616.53%
Perceptive Advisors LLC	86.67K	Jun 30, 2026	0.45%	$0.00	0.00%
Citadel Advisors Llc	86.19K	Jun 30, 2026	0.44%	$0.00	50.26%
XTX Topco Ltd	77.01K	Jun 30, 2026	0.40%	$0.00	216.07%
Geode Capital Management, LLC	62.19K	Jun 30, 2026	0.32%	$0.00	-15.83%
HRT FINANCIAL LLC	54.43K	Jun 30, 2026	0.28%	$0.00	0.00%
Susquehanna International Group, LLP	34.28K	Jun 30, 2026	0.18%	$0.00	0.00%
TRU INDEPENDENCE ASSET MANAGEMENT 2, LLC	13.00K	Jun 30, 2026	0.07%	$0.00	0.00%
TWO SIGMA SECURITIES, LLC	12.95K	Jun 30, 2026	0.07%	$0.00	0.00%
Vanguard Capital Management, LLC	12.85K	Jun 30, 2026	0.07%	$0.00	0.00%
Tower Research Capital LLC	6.09K	Jun 30, 2026	0.03%	$0.00	0.00%
Barclays PLC	1.44K	Jun 30, 2026	0.01%	$0.00	0.00%
SBI Securities Co Ltd	641.00	Jun 30, 2026	0.00%	$0.00	31.89%
BlackRock Inc	65.00	Jun 30, 2026	0.00%	$0.00	0.00%
DRW Securities, LLC	0.00	Mar 31, 2026	0.00%	$0.00	-100.00%
Williams & Novak LLC	0.00	Mar 31, 2026	0.00%	$0.00	-100.00%
UBS Group AG	0.00	Jun 30, 2026	0.00%	$0.00	-100.00%
FNY Investment Advisers, LLC	0.00	Jun 30, 2026	0.00%	$0.00	-100.00%
Fund Holdings

Rank	Holder Name	Shares Held	% of Shares	Change	Date Reported
1	Fidelity Extended Market Index	60.70K	0.31%	▼ 0.53%	Aug 31, 2026
Financial Highlights

▼
Market Cap: $8.75M
EBITDA: $-10.23M
Book Value: $-0.05
Earnings/Share: $-2.47
Profit Margin: -280.48%
Operating Margin: -221.28%
ROA (TTM): -185.51%
ROE (TTM): -1,295.09%
Revenue (TTM): $4.50M
Revenue/Share (TTM): $0.68
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): -15.10%
Valuation Metrics

Enterprise Value: $8.28M
Trailing P/E: 0.00
Forward P/E: 0.95
Shares Statistics

Shares Outstanding: 19.46M
Shares Float: 18.54M
% Insiders: 4.72%
% Institutions: 4.65%
Short % Float: 5.56%
Stock Price History

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Financial Charts

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Open balance sheet Open capital intensity Download Financials (Excel)
Revenue, Net Income & Operating Cash Flow (Yearly)

Change % vs Prior Year

Revenue, Net Income & Operating Cash Flow (Quarterly)

Change % vs Prior Quarter

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Income Statement Waterfall

▼
Line Item
Step Type
Value
Revenue
adjust
$5.07M
Cost of Goods Sold
adjust
$-10.38M
Gross Profit
subtotal
$-5.31M
SG&A
adjust
$-4.93M
R&D
adjust
$-10.38M
Operating Income
subtotal
$-10.24M
Other / Non-Operating Items
adjust
$65.25K
Net Income
subtotal
$-10.18M
Earnings Per Share (EPS) History

▼
Financial Ratios

▼
📦 Raw API Data (JSON Explorer)

▼
Comprehensive raw data returned from the EOD Fundamentals API. Expand sections below to drill down.
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}
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Fund Holdings

Financial Highlights

Valuation Metrics

Shares Statistics

Stock Price History

1 Year Price History

3 Years Price History

10 Years Price History

Max Price History

Financial Charts

Revenue, Net Income & Operating Cash Flow (Yearly)

Change % vs Prior Year

Revenue, Net Income & Operating Cash Flow (Quarterly)

Change % vs Prior Quarter

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Income Statement Waterfall

Earnings Per Share (EPS) History

Financial Ratios

📦 Raw API Data (JSON Explorer)

Assistant
