Stock Fundamentals

Company Information

Company Name
Centessa Pharmaceuticals PLC ADR
Sector
Healthcare
Industry
Biotechnology
Exchange
NASDAQ
ISIN: US1523091007
CIK: 0001847903
CUSIP: 152309100
Currency: USD
Full Time Employees: 129
Phone: 44 617 4685770
Fiscal Year End: December
IPO Date: May 28, 2021
Description:

Centessa Pharmaceuticals plc, together with its subsidiaries, discovers, develops, and delivers orexin-based neuroscience therapeutics in the United Kingdom and the United States. The company develops ORX750, an orexin receptor 2 agonist, which is in Phase IIa clinical trial for the treatment of central disorders of hypersomnolence, including narcolepsy type 1 and 2, as well as idiopathic hypersomnia. It also engages in the development of ORX142 which is in Phase I clinical trial for the treatment of neurological and neurodegenerative disorders; ORX489 which is in Phase I clinical trial for the treatment of neuropsychiatric disorders; and LockBody, an early-stage immuno-oncology program technology platform. The company was incorporated in 2020 and is headquartered in Altrincham, the United Kingdom.

Address:

1 Ashley Road, Altrincham, United Kingdom, WA14 2DT

Directors & Officers

Name Title Year Born
Mr. John J. Crowley CPA Chief Financial Officer 1974
Dr. Stephen J. Kanes M.D., Ph.D. Head of R&D and Chief Medical Officer 1965
Dr. Mario Alberto Accardi Ph.D. CEO & Director 1986
Mr. Raphael Deferiere CPA Senior VP & Chief Accounting Officer 1980
Ms. Tia L. Bush Chief Technology & Quality Officer 1971
Ms. Kristen K. Sheppard Esq., J.D. Senior Vice President of Investor Relations & Corporate Communications NA
Mr. Iqbal J. Hussain L.L.B. Chief Legal Officer, Chief Compliance Officer & Company Secretary 1981
Ms. Karen M. Anderson Chief People Officer 1968
Dr. Gregory M. Weinhoff M.B.A., M.D. Chief Business Officer 1971
Ms. Charlene Stoudt Senior Vice President of Clinical Development Operations NA

Insider Trading

Date Insider Name Title Transaction Type Shares Price Value
Mar 26, 2026 Karen M Anderson N/A Sale 41.08K $30.12 $1.24M
Mar 17, 2026 Karen M Anderson N/A Sale 10.04K $28.10 $282.21K
Mar 16, 2026 Karen M Anderson N/A Sale 64.77K $28.21 $1.83M
Mar 13, 2026 Gregory M Weinhoff N/A Sale 73.20K $26.33 $1.93M
Mar 13, 2026 Karen M Anderson N/A Sale 120.03K $26.25 $3.15M
Feb 02, 2026 Iqbal J Hussain N/A Sale 38.95K $25.15 $979.62K
Jan 30, 2026 Iqbal J Hussain N/A Sale 1.01K $25.01 $25.26K
Dec 08, 2025 Mario Alberto Accardi N/A Sale 10.00K $30.00 $300.00K
Nov 12, 2025 Tia L Bush N/A Sale 40.00K $26.00 $1.04M
Oct 27, 2025 Mario Alberto Accardi N/A Sale 8.00K $25.00 $200.00K
Oct 15, 2025 Iqbal J Hussain N/A Sale 6.00K $22.41 $134.46K
Sep 24, 2025 Tia L Bush N/A Sale 35.00K $24.00 $840.00K
Sep 16, 2025 Mario Alberto Accardi N/A Sale 8.17K $21.40 $174.88K
Sep 15, 2025 Iqbal J Hussain N/A Sale 6.00K $21.85 $131.10K
Sep 10, 2025 Tia L Bush N/A Sale 25.00K $22.00 $550.00K
Sep 09, 2025 Tia L Bush N/A Sale 24.79K $20.00 $495.84K
Sep 09, 2025 Mario Alberto Accardi N/A Sale 7.00K $20.00 $140.00K
Sep 09, 2025 Iqbal J Hussain N/A Sale 20.00K $20.01 $400.20K
Aug 15, 2025 Iqbal J Hussain N/A Sale 6.00K $17.23 $103.38K
Jul 29, 2025 Mario Alberto Accardi N/A Sale 8.32K $15.23 $126.74K

Institutional Holders

Holder Name Shares Date Reported % Out Value % Change
Medicxi Ventures Management (Jersey) Ltd 19.96M Mar 31, 2026 12.90% $80.76 0.00%
venBio Select Advisor LLC 11.43M Mar 31, 2026 7.39% $4.47 -21.47%
Index Venture Life Associates VI Ltd 9.96M Mar 31, 2026 6.44% $100.00 0.00%
Adage Capital Partners Gp LLC 8.93M Mar 31, 2026 5.77% $0.55 -20.89%
Pentwater Capital Management LP 8.17M Mar 31, 2026 5.28% $1.68 0.00%
FMR Inc 6.85M Mar 31, 2026 4.43% $0.01 -23.54%
EcoR1 Capital, LLC 6.00M Mar 31, 2026 3.88% $10.11 92.62%
Perceptive Advisors LLC 5.26M Mar 31, 2026 3.40% $4.08 80.25%
Capital World Investors 4.83M Mar 31, 2026 3.12% $0.03 317.07%
Farallon Capital Management, L.L.C. 4.81M Mar 31, 2026 3.11% $1.09 -10.56%
TCG Crossover Management, LLC 4.29M Mar 31, 2026 2.77% $4.87 0.00%
Morgan Stanley - Brokerage Accounts 4.27M Mar 31, 2026 2.76% $0.01 284.85%
Paradigm Biocapital Advisors LP 3.57M Mar 31, 2026 2.31% $2.90 0.00%
HHG PLC 3.49M Mar 31, 2026 2.26% $0.07 -14.67%
Deep Track Capital, LP 3.16M Mar 31, 2026 2.04% $2.05 57.90%
Logos Global Management LP 2.13M Mar 31, 2026 1.37% $4.21 962.50%
RTW INVESTMENTS, LLC 2.05M Mar 31, 2026 1.33% $0.81 14.70%
Federated Hermes Inc 2.05M Mar 31, 2026 1.32% $0.13 -12.50%
BRAIDWELL LP 1.99M Mar 31, 2026 1.28% $2.63 -9.21%
Bank of America Corp 1.93M Mar 31, 2026 1.25% $0.01 103.51%

Shares Statistics

Shares Outstanding: 154.73M
Shares Float: 92.48M
% Insiders: 51.50%
% Institutions: 9,698.40%
Short % Float: 1.96%

Fund Holdings

Rank Holder Name Shares Held % of Shares Change Date Reported
1 American Funds SMALLCAP World A 4.42M 2.86% ▲ 288.99% Mar 31, 2026
2 Fidelity Contrafund 1.32M 0.85% ▲ 0.00% Apr 30, 2026
3 Federated Hermes Kaufmann Growth 1.24M 0.80% ▲ 0.00% Mar 31, 2026
4 Federated Hermes Kaufmann R 1.24M 0.80% ▲ 0.00% Mar 31, 2026
5 Janus Henderson Triton D 853.85K 0.55% ▲ 0.00% Mar 31, 2026
6 Janus Henderson US SMID Cap Growth 853.85K 0.55% ▼ 2.40% Mar 31, 2026
7 Federated Hermes Kaufmann Small Cap A 787.00K 0.51% ▼ 27.11% Mar 31, 2026
8 Federated Hermes Kaufmann Small Cap Grow 787.00K 0.51% ▼ 27.11% Mar 31, 2026
9 Eventide Healthcare & Life Sciences I 668.14K 0.43% ▲ 0.00% Mar 31, 2026
10 Franklin US Small Cap Growth Equity 590.82K 0.38% ▼ 1.73% Mar 31, 2026

Valuation Metrics

Enterprise Value: $5.99B
Trailing P/E: 0.00
Forward P/E: 0.00

Financial Highlights

Market Cap: $6.15B
EBITDA: $-256.34M
Book Value: $3.15
Earnings/Share: $-1.78
Profit Margin: 0.00%
Operating Margin: 0.00%
ROA (TTM): -27.43%
ROE (TTM): -57.38%
Revenue (TTM): $0.00
Revenue/Share (TTM): $0.00
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): 0.00%

Stock Price History

1 Year Price History

2 Years Price History

5 Years Price History

10 Years Price History

Financial Charts

Revenue & Net Income (Yearly)

Revenue & Net Income (Quarterly)

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Earnings Per Share (EPS) History

Financial Ratios

Balance Sheet (Yearly)

Financial Ratios

Date Current Ratio Debt/Equity Debt/Assets Interest Coverage Debt/EBITDA
2025-12-31 8.57x 0.21x 0.23x -18.12x -0.60x
2024-12-31 9.25x 0.27x 0.30x -19.93x -0.49x
2023-12-31 8.00x 0.32x 0.34x -17.29x -0.46x
2022-12-31 11.42x 0.21x 0.24x -29.17x -0.33x
2021-12-31 25.52x 0.15x 0.22x -147.08x -0.54x
2020-12-31 1.30x 1.82x 0.74x -27.62x -0.55x
2019-12-31 9.95x 0.30x 0.31x -42.82x -0.82x

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