APRE
Aprea Therapeutics Inc

APRE.US aprea.com + Research + Basket
Healthcare · Biotechnology
CIK 0001781983
Employees 8
Phone 215 948 4119
Fiscal year end December
IPO Oct 03, 2019
Address 3805 Old Easton Road, Doylestown, PA, United States, 18902
0.51
+0.06 (+14.25%)
USD · NASDAQ
52-week range
0.41
1.47
Trading at 10% of the 52-week range
Market Cap
5.65M
P/E Ratio
0.00
Forward P/E
0.00
Book Value
3.11
Div. Yield
N/A
% Institutions
18.83%
% Insiders
9.17%
1 Year

-61.7%
3 Year

-85.7%
10 Year

-99.9%
Description
Aprea Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing novel synthetic lethality-based cancer therapeutics that targets DNA damage response pathways. Its lead product candidates are APR-1051, an orally bioavailable small-molecule inhibitor of WEE1 kinase that is in Phase 1 clinical trial for the treatment of patients with advanced solid tumors with biomarkers and ATRN-119, an ATR inhibitor, which is in Phase 1/2a clinical trial for solid tumor indications. The company is headquartered in Doylestown, Pennsylvania.
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People

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Directors & Officers

Name	Title	Year Born
Dr. Oren Gilad Ph.D.	Co-Founder, CEO, President & Director	1968
Mr. John P. Hamill CPA	Senior VP, CFO, Principal Accounting Officer & Secretary	1964
Dr. Lars B. Abrahmsen Ph.D.	Senior VP & Chief Scientific Officer	1957
Mr. Brian Wiley	Senior Vice President of Corporate Development & Strategy	1968
Dr. Michel Afargan Ph.D.	Head of Pharmacology Development	NA
Mr. Ze'ev Weiss B.Sc., C.P.A.	Chief Business Advisor	1962
Dr. Eugene P. Kennedy F.A.C.S., M.D.	Chief Medical Advisor	1969
Ms. Andrea Epstein	Controller	NA
Insider Trading

Open insider trading
Date	Insider Name	Title	Transaction Type	Shares	Price	Value	SEC
Dec 10, 2025	John P Hamill	N/A	Purchase	5.00K	$1.17	$5.85K	SEC
Dec 10, 2025	Marc Duey	N/A	Purchase	21.46K	$1.17	$25.11K	SEC
Shareholders

▼
Institutional Holders

Holder Name	Shares	Date Reported	% Out	Value	% Change
AIGH Capital Management, LLC	1.02M	Jun 30, 2026	8.07%	$0.05	0.00%
Nantahala Capital Management, LLC	411.52K	Jun 30, 2026	3.27%	$0.01	100.00%
Vestal Point Capital LP	350.00K	Jun 30, 2026	2.78%	$0.01	0.00%
Sphera Funds Management Ltd.	270.00K	Jun 30, 2026	2.14%	$0.03	0.00%
Renaissance Technologies Corp	105.80K	Jun 30, 2026	0.84%	$0.00	321.51%
Geode Capital Management, LLC	74.87K	Jun 30, 2026	0.59%	$0.00	-37.15%
Citadel Advisors Llc	58.60K	Jun 30, 2026	0.47%	$0.00	0.00%
BNP Paribas Arbitrage, SA	45.21K	Jun 30, 2026	0.36%	$0.00	13.55%
Diadema Partners LP	44.91K	Jun 30, 2026	0.36%	$0.00	0.00%
Vanguard Fiduciary Trust Co	38.46K	Jun 30, 2026	0.31%	$0.00	0.00%
Susquehanna International Group, LLP	34.94K	Jun 30, 2026	0.28%	$0.00	168.39%
Morgan Stanley - Brokerage Accounts	25.83K	Jun 30, 2026	0.21%	$0.00	15.67%
Vanguard Capital Management, LLC	22.88K	Jun 30, 2026	0.18%	$0.00	16.61%
LPL Financial Corp	16.05K	Jun 30, 2026	0.13%	$0.00	-23.75%
HighTower Advisors, LLC	13.86K	Jun 30, 2026	0.11%	$0.00	0.00%
Northern Trust Corp	13.71K	Jun 30, 2026	0.11%	$0.00	0.00%
Persistent Asset Partners Limited	11.49K	Jun 30, 2026	0.09%	$0.00	0.00%
XTX Topco Ltd	10.57K	Jun 30, 2026	0.08%	$0.00	0.00%
BlackRock Inc	7.17K	Jun 30, 2026	0.06%	$0.00	-15.65%
Tower Research Capital LLC	3.59K	Jun 30, 2026	0.03%	$0.00	-29.98%
Fund Holdings

Rank	Holder Name	Shares Held	% of Shares	Change	Date Reported
1	Fidelity Extended Market Index	59.62K	0.47%	▼ 0.53%	Aug 31, 2026
2	Fidelity Total Market Index	7.20K	0.06%	▲ 0.00%	Aug 31, 2026
3	Fidelity Series Total Market Index	5.85K	0.05%	▲ 0.00%	Aug 31, 2026
4	BlackRock Diversified Equity Alpha Inst	289.00	0.00%	▲ 0.00%	Jul 31, 2026
Financial Highlights

▼
Market Cap: $5.65M
EBITDA: $-13.20M
Book Value: $3.11
Earnings/Share: $-0.95
Profit Margin: 0.00%
Operating Margin: -255,025.51%
ROA (TTM): -27.73%
ROE (TTM): -46.15%
Revenue (TTM): $5.19K
Revenue/Share (TTM): $0.00
Earnings Growth (YOY): 0.00%
Revenue Growth (YOY): -98.40%
Valuation Metrics

Enterprise Value: $-34.71M
Trailing P/E: 0.00
Forward P/E: 0.00
Shares Statistics

Shares Outstanding: 12.59M
Shares Float: 7.90M
% Insiders: 9.17%
% Institutions: 18.83%
Short % Float: 4.29%
Stock Price History

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1 Year Price History

3 Years Price History

10 Years Price History

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Financial Charts

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Open balance sheet Open capital intensity Download Financials (Excel)
Revenue, Net Income & Operating Cash Flow (Yearly)

Change % vs Prior Year

Revenue, Net Income & Operating Cash Flow (Quarterly)

Change % vs Prior Quarter

Operating Expenses (Yearly)

Operating Expenses (Quarterly)

Balance Sheet (Yearly)

Balance Sheet (Quarterly)

Assets Breakdown (Yearly)

Assets Breakdown (Quarterly)

Liabilities Breakdown (Yearly)

Liabilities Breakdown (Quarterly)

Income Statement Waterfall

▼
Line Item
Step Type
Value
Revenue
adjust
$285.76K
Cost of Goods Sold
adjust
$-21.72K
Gross Profit
subtotal
$264.04K
SG&A
adjust
$-6.48M
R&D
adjust
$-7.04M
Operating Income
subtotal
$-13.23M
Other / Non-Operating Items
adjust
$634.27K
Net Income
subtotal
$-12.60M
Earnings Per Share (EPS) History

▼
Financial Ratios

▼
📦 Raw API Data (JSON Explorer)

▼
Comprehensive raw data returned from the EOD Fundamentals API. Expand sections below to drill down.
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}
Aprea Therapeutics Inc

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